Circadian Rhythms and Sleep in Aging: Impact On the 24-hour Hormonal Profiles
Résumé
The 24-hour temporal regulation of hormonal secretions results from the interaction of an endogenous circadian pacemaker and of sleep-wake homeostasis, a mechanism linking the timing and the intensity of sleep to the duration of prior wakefulness. A prominent age-related alteration of hormonal circadian rhythmicity is characterized by a reduction in rhythm amplitude and a phase advance. At the same time, the sleep-wake pattern undergoes major modifications, with a spectacular decrease in “restorative” sleep stage from early adulthood to mid-life, followed thereafter by sleep fragmentation and a decrease in total sleep time. Age-related sleep and endocrine-metabolic alterations frequently interact with each other.
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A comme version hal-04993425 Chapitre d'ouvrage Karine Spiegel, Anne Caufriez, Georges Copinschi. Circadian rhythms and sleep in aging: Impact on 24-hour hormonal profiles. Reference Module in Biomedical Sciences, Elsevier, 2024, ⟨10.1016/B978-0-443-13825-6.00097-2⟩. ⟨hal-04993425⟩