Neuronal RNP granules: from physiological to pathological assemblies - Archive ouverte HAL
N°Spécial De Revue/Special Issue Biological Chemistry Année : 2018

Neuronal RNP granules: from physiological to pathological assemblies

Florence Besse

Résumé

Neuronal cells rely on macro- and micro-cellular compartmentalization to rapidly process information, and respond locally to external stimuli. Such a cellular organization is achieved via the assembly of neuronal rib- onucleoprotein (RNP) granules, dynamic membrane-less organelles enriched in RNAs and associated regulatory proteins. In this review, we discuss how these high-order structures transport mRNAs to dendrites and axons, and how they contribute to the spatio-temporal regulation of localized mRNA translation. We also highlight how recent biophysical studies have shed light on the mechanisms underlying neuronal RNP granule dynamic assembly, remodeling and maturation, in both physiological and pathological contexts.
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Dates et versions

hal-04720663 , version 1 (03-10-2024)

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Fabienne de Graeve, Florence Besse. Neuronal RNP granules: from physiological to pathological assemblies. Biological Chemistry, 399 (7), pp.623-635, 2018, ⟨10.1515/hsz-2018-0141⟩. ⟨hal-04720663⟩
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