Is pressurized intraperitoneal aerosol chemotherapy (PIPAC) feasible in a rabbit model of gastric peritoneal metastases?
Résumé
Currently, peritoneal metastases (PM) represent a poor prognosis in cancer and chemotherapy techniques are very limited (Cortés-Guiral et al 2021 Nat Rev Dis Primers). Pressurized intra-peritoneal aerosol chemotherapy (PIPAC) appears to be a new and more effective treatment method (Kepenekian et al 2022 Nat rev Clin Oncol). However, the development of a new protocol requires animal experiments (Taibi et al 2019 Plos One). In this study, the feasibility of the technique on the healthy lagomorph model was tested with a view to subsequently testing the efficacy of this procedure on a lagomorph model with peritoneal metastases. The aim was to assess the safety and viability of repetitive PIPAC procedures in a rabbit model.