Immigrant populations have been shown to display a disproportionately high mortality burden during the Covid-19 epidemic in some high-income countries. Individual civil registration data from Spain, one of the countries with the highest Covid-19 mortality in Europe, was used in order to characterize mortality during the Covid-19 epidemic for different immigrant groups. Individuals born in South America, Sub-Saharan Africa and Asia are shown to have suffered higher mortality impact than the native-born, particularly at working ages (40–59 years old), which could be due to higher proportions of immigrants from these regions among key workers. However, this disproportionate impact is not as high as found in other European countries, like France or Sweden. On the other hand, immigrants born in Europe show a relatively low mortality increment during the epidemic compared to the native-born. In addition, evidence is shown of a generalized and strong migrant mortality advantage for all non-European immigrant groups in Spain, that reduces or even reverses for some groups of countries of birth in 2020.