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                <term xml:lang="en">Type 1</term>
                <term xml:lang="en">Secondary prevention</term>
                <term xml:lang="en">LDL</term>
                <term xml:lang="en">Hypolipidemic agents</term>
                <term xml:lang="en">Heart disease risk factors</term>
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              <p>Aims -:As people with type 1 diabetes have increased risk of cardiovascular morbi-mortality,management of cardiovascular risk factors is of crucial importance. We assessed theprevalence and factors associated with LDL-cholesterol (LDL-c) target achievement inpatients with type 1 diabetes at high and very-high cardiovascular risk.Methods -:In this observational multicenter study, we included hospitalized patients with type 1 diabeteswho had a fasting blood lipid analysis at admission. Cardiovascular risk level and LDL-ctarget values were defined according to ESC/EAS guidelines into force at admission: LDL-ctarget for very-high risk (VHR) and high risk (HR) patients was 1.4 and 1.8 mmol/lrespectively for patients included from September 2019 (2019 guidelines) and 1.8 and 2.6mmol/l respectively for patients included in 2016-2019 (2016 guidelines). LDL-c targetattainment was assessed in HR and VHR patients, and factors associated with attainment wereidentified with multivariable analysis.Results -:We included 85 HR patients (median age 37y [interquartile range: 27;45], 64% females) and356 VHR patients (49 [35;61] years, 42% females). In HR patients, 7% were treated withstatins, and 35.3% achieved the LDL-c target. Increasing age (odds ratio 0.58 [95%confidence interval: 0.38;0.89]), body mass index (0.86 [0.75;0.98]), and HbA1c (0.69[0.50;0.94]) were independently associated with lower odds of attaining LDL-c target. InVHR patients, 36% were treated with statins, and 17.4% achieved LDL-c target. Statintreatment (2.33 [1.22;4.43]), secondary prevention (2.33 [1.21;4.48]) and chronic renal failure(2.82 [1.42;5.61]) were associated with higher odds of attaining LDL-c target.Conclusion -:Control of LDL-c is highly insufficient in both HR and VHR patients. Cardiovascular riskevaluation and better control of risk factors may help decrease cardiovascular morbi-mortalityin patients with type 1 diabetes.</p>
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