Oxide Dispersion Strengthened (ODS) steels hold great promise for applications in next generation reactors. Under irradiation, a phase separation α/ α’ can occur within the Fe-Cr matrix of ODS steels that can alter their mechanical properties. This work presents, for the first time, the characteristics of α’ precipitates enhanced by ion irradiation at 400 °C and examines the influence of the implanted ions. Far from the implanted region, α’ is reported in significant density while at the implanted peak, the α’ density is considerably reduced. This suggests that ion implantation either reduces the fraction of α’ phase formed after irradiation or delays considerably its formation. Through atom probe tomography analysis and comparison with existing literature, the low impact of the damage rate and fluence on the α’ formation in ODS steels is highlighted. Interestingly, the efficiency of ballistic mixing of α’ appears to be less pronounced in ODS steels than in Fe-Cr systems.