Treatment of moderate-to-severe psoriasis in adults: An expert consensus statement using a Delphi method to produce a decision-making algorithm - Archive ouverte HAL
Article Dans Une Revue Annales de Dermatologie et de Vénéréologie Année : 2024

Treatment of moderate-to-severe psoriasis in adults: An expert consensus statement using a Delphi method to produce a decision-making algorithm

Florence Poizeau (1, 2) , S Leducq (3) , L Fardet (4) , Marie Beylot-Barry (5) , Guillaume Chaby (6, 7) , M Chastagner (8) , F Corgibet (6) , L. Gouillon (8) , N Jouan (6) , D. Jullien (8) , A Acher , F. Amatore (9) , J. M. Amici (5) , H Aubert (10) , F Aubin (11) , N Beneton (12) , D Bouilly , A-C Bursztejn (13) , C Buzenet , M Chamaillard-Pujol , J Charles (14) , A-C Cottencin-Charriere (13) , B Duval Modeste , A Fauconneau , Anne-Claire Fougerousse (13) , C Girard (15) , C Goujon (16) , A. Khemis (17) , Y Le Ru , C Lepelley-Dupont , E. Mahé (18) , X Marcellin , C Nicolas (19) , V Pallure (20, 21) , J Parier , N Quiles , P-E Stoebner (2) , M Tauber , A Vermersch , M Viguier , A.P. Villani (8) , Olivier Chosidow , B Guillot
1 Centre Hospitalier Universitaire [Rennes]
2 Irset - Institut de recherche en santé, environnement et travail
3 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
4 EpiDermE - Epidemiology in Dermatology and Evaluation in Therapeutics
5 BPH - Bordeaux population health
6 Centre de Preuves en Dermatologie
7 CHU Amiens-Picardie
8 HCL - Hospices Civils de Lyon
9 AMU - Aix Marseille Université
10 Nantes Univ - Nantes Université
11 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
12 Centre Hospitalier Le Mans (CH Le Mans)
13 CHU Nancy - Centre Hospitalier Universitaire de Nancy
14 CPT - Centre de Physique Théorique - UMR 7332
15 CHU de Montpellier, Montpellier, France
16 IRIM - Institut de Recherche en Infectiologie de Montpellier
17 University Abbes Laghrour Khenchela
18 CH Argenteuil - Centre hospitalier Argenteuil
19 SSOLEIL - Synchrotron SOLEIL
20 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
21 Pathogénèse et contrôle des infections chroniques (PCCI)
Florence Poizeau
Connectez-vous pour contacter l'auteur
Centre Hospitalier Universitaire [Rennes]
Institut de recherche en santé, environnement et travail
S Leducq
MethodS in Patients-centered outcomes and HEalth ResEarch
CV
L Fardet
Epidemiology in Dermatology and Evaluation in Therapeutics
Marie Beylot-Barry
Bordeaux population health
Guillaume Chaby
Centre de Preuves en Dermatologie
CHU Amiens-Picardie
M Chastagner
  • Fonction : Auteur
Hospices Civils de Lyon
F Corgibet
  • Fonction : Auteur
Centre de Preuves en Dermatologie
L. Gouillon
Hospices Civils de Lyon
N Jouan
  • Fonction : Auteur
Centre de Preuves en Dermatologie
D. Jullien
Hospices Civils de Lyon
A Acher
  • Fonction : Auteur
F. Amatore
Aix Marseille Université
J. M. Amici
  • Fonction : Auteur
Bordeaux population health
H Aubert
Nantes Université
F Aubin
Centre Hospitalier Régional Universitaire de Besançon
N Beneton
Centre Hospitalier Le Mans (CH Le Mans)
D Bouilly
  • Fonction : Auteur
A-C Bursztejn
Centre Hospitalier Universitaire de Nancy
C Buzenet
  • Fonction : Auteur
M Chamaillard-Pujol
  • Fonction : Auteur
J Charles
  • Fonction : Auteur
Centre de Physique Théorique - UMR 7332
A-C Cottencin-Charriere
  • Fonction : Auteur
Centre Hospitalier Universitaire de Nancy
B Duval Modeste
  • Fonction : Auteur
A Fauconneau
Anne-Claire Fougerousse
Centre Hospitalier Universitaire de Nancy
C Girard
  • Fonction : Auteur
CHU de Montpellier, Montpellier, France
C Goujon
Institut de Recherche en Infectiologie de Montpellier
A. Khemis
University Abbes Laghrour Khenchela
Y Le Ru
C Lepelley-Dupont
  • Fonction : Auteur
E. Mahé
Centre hospitalier Argenteuil
X Marcellin
  • Fonction : Auteur
C Nicolas
  • Fonction : Auteur
Synchrotron SOLEIL
V Pallure
  • Fonction : Auteur
Centre Hospitalier Régional Universitaire [Montpellier]
Pathogénèse et contrôle des infections chroniques (PCCI)
J Parier
  • Fonction : Auteur
N Quiles
  • Fonction : Auteur
P-E Stoebner
  • Fonction : Auteur
Institut de recherche en santé, environnement et travail
M Tauber
  • Fonction : Auteur
A Vermersch
  • Fonction : Auteur
M Viguier
A.P. Villani
Hospices Civils de Lyon
Olivier Chosidow
B Guillot

Résumé

Background: New highly effective drugs for moderate-to-severe cutaneous psoriasis are regularly marketed, and the hierarchy of treatments thus requires frequent review. Objectives: A Delphi method was used to enable a structured expert consensus on the use of systemic treatments and phototherapy among adults with moderate-to-severe psoriasis. Methods: The Delphi method consists in achieving a convergence of opinions among a panel of experts using several rounds of questionnaires with controlled feedback between rounds. A two-part Delphi questionnaire was administered online to French psoriasis experts. In the first part, 180 items related to the prescription of systemic treatments and phototherapy for adult patients with moderate-to-severe psoriasis were grouped into 21 sections covering different lines of treatment and different forms of cutaneous psoriasis. The experts voted on each proposal using an ordinal 7-point Likert scale. The second part comprised 11 open-ended questions about special indications for each therapeutic class. These were converted into 101 questions for subsequent rounds. Consensus was deemed to have been reached if more than 80% of the experts agreed with a given proposal. Results: Three rounds of questionnaires were sequentially sent to 35 participants between November 2021 and March 2022. Thirty-three (94%) completed all three rounds. For plaque psoriasis, only methotrexate was recommended by the experts as first-line systemic treatment (89% of votes). Cyclosporin was advocated in pustular and erythrodermic psoriasis, and acitretin was suggested for hyperkeratotic and palmoplantar psoriasis. In the event of failure of or intolerance to non-biological systemic treatments, guselkumab, risankizumab, ixekizumab or secukinumab were recommended by more than 80% of the experts. Tumor Necrosis Factor (TNF) inhibitors remain useful for patients with cardiovascular risk factors. Special indications were provided for each therapeutic class (methotrexate/narrowband ultraviolet B phototherapy, psoralen/ultraviolet A phototherapy, cyclosporin, acitretin, apremilast, TNF inhibitors, interleukin (IL)-12/23 inhibitors, IL-17(R)A inhibitors, and IL-23 inhibitors). Conclusions: This expert consensus statement indicate that newly available IL-17 and IL-23 inhibitors may be favored over TNF and IL-12/23 inhibitors as first-line biologics. The Centre of Evidence of the French Society of Dermatology has drawn up a decision-making algorithm to guide clinicians in the therapeutic management of moderate-to-severe psoriasis.

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Sciences du Vivant [q-bio]

Laurent Jonchère  : Connectez-vous pour contacter le contributeur

https://hal.science/hal-04689111

Soumis le : jeudi 5 septembre 2024-14:39:37

Dernière modification le : jeudi 7 novembre 2024-16:14:04

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hal-04689111 , version 1 (05-09-2024)

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Florence Poizeau, S Leducq, L Fardet, Marie Beylot-Barry, Guillaume Chaby, et al.. Treatment of moderate-to-severe psoriasis in adults: An expert consensus statement using a Delphi method to produce a decision-making algorithm. Annales de Dermatologie et de Vénéréologie, 2024, 151 (3), pp.103287. ⟨10.1016/j.annder.2024.103287⟩. ⟨hal-04689111⟩

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HCL UNIV-RENNES1 UNIV-TLN UNIV-TOURS CNRS UNIV-AMU UNIV-ANGERS CPT UPEC IRSET UR1-UFR-SVE SYNCHROTRON-SOLEIL BS UNIV-MONTPELLIER UNIV-RENNES PCCI EPIDERME IRSET-11 UR1-BIO-SA SPHERE_HEALTH_RESEARCH U1219 GS-PHYSIQUE INSTITUT-SCIENCES-LUMIERE NANTES-UNIVERSITE IRIM
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