Targeting the liver clock improves fibrosis by restoring TGF-β signaling.
Emilie Crouchet
(1)
,
Mayssa Dachraoui
(1)
,
Frank Jühling
(1)
,
Natascha Roehlen
(1, 2)
,
Marine Oudot
(1)
,
Sarah C. Durand
(1)
,
Clara Ponsolles
(1)
,
Cloé Gadenne
(1)
,
Laura Meiss-Heydmann
(1)
,
Julien Moehlin
(1)
,
Romain Martin
(1)
,
Nicolas Brignon
(1)
,
Fabio del Zompo
(1)
,
Yuji Teraoka
,
Hiroshi Aikata
,
Hiromi Abe-Chayama
,
Kazuaki Chayama
,
Antonio Saviano
(1, 3)
,
Danijela Heide
,
Mihaela Onea
(3)
,
Lucas Geyer
(3)
,
Thibaut Wolf
(3)
,
Emanuele Felli
(1, 4)
,
Patrick Pessaux
(1, 3)
,
Mathias Heikenwälder
,
Pierre Chambon
(5)
,
Catherine Schuster
(1)
,
Joachim Lupberger
(1)
,
Atish Mukherji
(1, 5)
,
Thomas F. Baumert
(1, 6, 7)
1
ITM -
Institute for Translational Medicine and Liver Disease
2 Uniklinik - Universitäts Klinikum Freiburg = University Medical Center Freiburg
3 HUS - Les Hôpitaux Universitaires de Strasbourg
4 Groupe Hospitalier Saint-Vincent
5 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
6 IHU Strasbourg - L'Institut hospitalo-universitaire de Strasbourg
7 IUF - Institut universitaire de France
2 Uniklinik - Universitäts Klinikum Freiburg = University Medical Center Freiburg
3 HUS - Les Hôpitaux Universitaires de Strasbourg
4 Groupe Hospitalier Saint-Vincent
5 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
6 IHU Strasbourg - L'Institut hospitalo-universitaire de Strasbourg
7 IUF - Institut universitaire de France
Emilie Crouchet
- Function : Author
- PersonId : 1062860
Mayssa Dachraoui
- Function : Author
- PersonId : 1078727
Frank Jühling
- Function : Author
- PersonId : 1101238
Natascha Roehlen
- Function : Author
- PersonId : 1062945
Marine Oudot
- Function : Author
- PersonId : 1059082
Clara Ponsolles
- Function : Author
- PersonId : 1234448
Cloé Gadenne
- Function : Author
- PersonId : 1412047
Laura Meiss-Heydmann
- Function : Author
- PersonId : 1059417
Romain Martin
- Function : Author
- PersonId : 1234449
Fabio del Zompo
- Function : Author
- PersonId : 1234446
Yuji Teraoka
- Function : Author
Hiroshi Aikata
- Function : Author
Hiromi Abe-Chayama
- Function : Author
Kazuaki Chayama
- Function : Author
Antonio Saviano
- Function : Author
- PersonId : 1178835
- ORCID : 0000-0001-7585-472X
Danijela Heide
- Function : Author
Patrick Pessaux
- Function : Author
- PersonId : 1059086
- ORCID : 0000-0001-5635-7437
- IdRef : 06911014X
Mathias Heikenwälder
- Function : Author
Pierre Chambon
- Function : Author
- PersonId : 1287403
- ORCID : 0000-0002-7861-6046
Catherine Schuster
- Function : Author
- PersonId : 761367
- ORCID : 0000-0001-7281-4511
- IdRef : 121095789
Joachim Lupberger
- Function : Author
- PersonId : 760769
- ORCID : 0000-0003-3996-3907
Atish Mukherji
- Function : Author
- PersonId : 1059700
Thomas F. Baumert
- Function : Author
- PersonId : 740312
- IdHAL : thomas-f-baumert
- IdRef : 143387898
Abstract
Liver fibrosis is the major driver for hepatocellular carcinoma and liver disease related death. Approved anti-fibrotic therapies are absent and compounds in development have limited efficacy. Increased TGF-β signaling drives collagen deposition by hepatic stellate cells (HSC)/myofibroblasts. Here, we aimed to dissect the role of the circadian clock (CC) in controlling TGF-β signaling and liver fibrosis.
Domains
Human health and pathology
Embargoed file
Embargoed file
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Friday, February 21, 2025