Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice
Ting Wong
(1)
,
Alexander Horspool
(1)
,
Brynnan Russ
(1)
,
Chengjin Ye
(2)
,
Katherine Lee
(1)
,
Michael Winters
(1)
,
Justin Bevere
(1)
,
Olivia Miller
(1)
,
Nathaniel Rader
(1)
,
Melissa Cooper
(1)
,
Theodore Kieffer
(3)
,
Julien Sourimant
(4)
,
Alexander Greninger
(5)
,
Richard Plemper
(4)
,
James Denvir
(6)
,
Holly Cyphert
(7)
,
Mariette Barbier
(1)
,
Jordi Torrelles
(2)
,
Ivan Martinez
(1)
,
Luis Martinez-Sobrido
(2)
,
F. Heath Damron
(1)
1
Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA
2 Texas Biomedical Research Institute [San Antonio, TX]
3 Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA
4 Georgia State University
5 Virology Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
6 Department of Biomedical Sciences, Marshall University, Huntington, West Virginia, USA
7 Department of Biological Sciences, Marshall University, Huntington, West Virginia, USA
2 Texas Biomedical Research Institute [San Antonio, TX]
3 Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA
4 Georgia State University
5 Virology Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
6 Department of Biomedical Sciences, Marshall University, Huntington, West Virginia, USA
7 Department of Biological Sciences, Marshall University, Huntington, West Virginia, USA
Alexander Horspool
- Fonction : Auteur
- PersonId : 1408409
- ORCID : 0000-0003-4115-0331
Julien Sourimant
- Fonction : Auteur
- PersonId : 1246851
- IdHAL : julien-sourimant
- ORCID : 0000-0002-1660-1666
Alexander Greninger
- Fonction : Auteur
- PersonId : 1408390
- ORCID : 0000-0002-7443-0527
Mariette Barbier
- Fonction : Auteur
- PersonId : 1408410
- ORCID : 0000-0002-3250-3636
Luis Martinez-Sobrido
- Fonction : Auteur
- PersonId : 1408391
- ORCID : 0000-0001-7084-0804
F. Heath Damron
- Fonction : Auteur
- PersonId : 1408411
- ORCID : 0000-0002-3140-402X
Résumé
Emerging SARS-CoV-2 VoC are posing new problems regarding vaccine and monoclonal antibody efficacy. To better understand immune evasion tactics of the VoC, we utilized passive immunization to study the effect of early-pandemic SARS-CoV-2 HCP against, Alpha, Beta, and Delta VoC.