Optically pure β-substituted β-hydroxy aspartates as glutamate transporter blockers
Résumé
A short asymmetric synthesis of optically pure β-substituted β-hydroxy aspartates is described. The key step is an aldol reaction between a glycine enolate derived from an oxazinone intermediate used as chiral auxiliary and various α-keto esters. Excellent diastereomeric excesses are obtained.
| Origine | Accord explicite pour ce dépôt |
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