Photorelease of nitric oxide from Pluronic F127/chitosan hydrogels incorporating a water soluble ruthenium nitrosyl complex - Archive ouverte HAL
Article Dans Une Revue New Journal of Chemistry Année : 2024

Photorelease of nitric oxide from Pluronic F127/chitosan hydrogels incorporating a water soluble ruthenium nitrosyl complex

Marine Tassé
Yue Xiao

Résumé

In this paper, the NO donor trans-(Cl,Cl)-[Ru(FT)Cl$_2$(NO)]Cl (Ru–NO) was incorporated in a Pluronic F127 (PL)–chitosan (CS) biocompatible hydrogel. Two concentrations were achieved (520 and 13 μg g$^{−1}$), resulting in hydrogels with sol–gel transition temperatures of around 36–38°C, according to rheological studies. The presence of the Ru–NO complex did not significantly modify the thermal (DSC) and morphological (AFM) characteristics of the gels. For Ru–NO-embedded hydrogels, nitric oxide photorelease was evidenced at 400 nm. The quantum yield of photorelease was independent of the temperature at which the gel was maintained (25, 31, or 37°C) and was found to be ca. 0.015. EPR as well as measurements using an electrochemical NO sensor also confirmed NO release upon light irradiation at 400 nm.
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Dates et versions

hal-04668795 , version 1 (07-08-2024)

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Hazem Gzam, Dalel Katar, Marine Tassé, Yue Xiao, Isabelle Malfant, et al.. Photorelease of nitric oxide from Pluronic F127/chitosan hydrogels incorporating a water soluble ruthenium nitrosyl complex. New Journal of Chemistry, 2024, 48 (18), pp.8343 - 8351. ⟨10.1039/d4nj00724g⟩. ⟨hal-04668795⟩
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