The physics of cancer: The role of epigenetics and chromosome conformation in cancer progression - Archive ouverte HAL
Article Dans Une Revue (Article De Synthèse) AIP Conference Proceedings Année : 2016

The physics of cancer: The role of epigenetics and chromosome conformation in cancer progression

Résumé

Cancer progression is generally described in terms of accumulated genetic alterations and ensuing changes in cell properties. However, intermediary modifications are involved in the establishment of cancer cell phenotypes, at different levels of nuclear organization: DNA damages and their structural consequences, epigenetic modifications and their impact on chromatin architecture, changes in chromosome 3D organization. We review some of these alterations with a focus on their physical aspects. The challenge is to understand the multiscale interplay between generic physical mechanisms and specific biological factors in cancer cells. We argue that such an interdisciplinary perspective offers a novel viewpoint on cancer progression, early diagnosis and possibly therapeutic targets.
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Dates et versions

hal-04666603 , version 1 (01-08-2024)

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Oleg B Naimark, Aleksandr S Nikitiuk, Marie-Odile Baudement, Thierry Forné, Annick Lesne. The physics of cancer: The role of epigenetics and chromosome conformation in cancer progression. AIP Conference Proceedings, 2016, International Conference on Physics of Cancer, 1760 (1), pp.020051. ⟨10.1063/1.4960270⟩. ⟨hal-04666603⟩
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