Cancer risk in patients with sleep apnoea following adherent 5-year CPAP therapy - Archive ouverte HAL
Article Dans Une Revue European Respiratory Journal Année : 2022

Cancer risk in patients with sleep apnoea following adherent 5-year CPAP therapy

Grégoire Justeau
  • Fonction : Auteur
Chloé Gervès-Pinquié
  • Fonction : Auteur
Wojciech Trzepizur
  • Fonction : Auteur
Nicole Meslier
François Goupil
  • Fonction : Auteur
Thierry Pigeanne
  • Fonction : Auteur
Sandrine Launois
  • Fonction : Auteur
Laurene Leclair-Visonneau
Philippe Masson
  • Fonction : Auteur
Acya Bizieux-Thaminy
  • Fonction : Auteur
Jean-Louis Racineux
  • Fonction : Auteur
David Gozal
Frédéric Gagnadoux

Résumé

Background Increasing evidence suggests that obstructive sleep apnoea (OSA) contributes to cancer risk; however, limited data are available on the impact of continuous positive airway pressure (CPAP) therapy on cancer incidence. We aimed to determine whether adherence to CPAP therapy is associated with a reduction in all-cancer incidence compared with nonadherent patients with OSA. Methods The study relied on data collected by the multicentre Pays de la Loire Sleep Cohort study, linked to health administrative data, so as to identify new-onset cancer. We included patients who were prescribed CPAP for OSA, with no history of cancer before the diagnostic sleep study or during the first year of CPAP. Patients with documented CPAP use for ≥4 h per night were defined as adherent. Those who discontinued or used CPAP <4 h per night constituted the nonadherent group. A propensity score inverse probability of treatment weighting analysis was performed to assess the effect of CPAP adherence on cancer risk. Results After a median (interquartile range) follow-up of 5.4 (3.1–8.0) years, 437 (9.7%) out of 4499 patients developed cancer: 194 (10.7%) in the nonadherent group (n=1817) and 243 (9.1%) in adherent patients (n=2682). The final weighted model showed no significant impact of CPAP adherence on all-cause cancer risk (subdistribution hazard ratio 0.94, 95% CI 0.78–1.14). Conclusions Adherence to CPAP therapy in OSA patients was not associated with a reduction in all-cancer incidence. Whether adherent CPAP therapy of OSA might reduce the risk of specific cancer sites should be further evaluated.

Dates et versions

hal-04659200 , version 1 (22-07-2024)

Identifiants

Citer

Grégoire Justeau, Sebastien Bailly, Chloé Gervès-Pinquié, Wojciech Trzepizur, Nicole Meslier, et al.. Cancer risk in patients with sleep apnoea following adherent 5-year CPAP therapy. European Respiratory Journal, 2022, 59 (4), pp.2101935. ⟨10.1183/13993003.01935-2021⟩. ⟨hal-04659200⟩

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