Incidence and risk factors of prolonged grief in relatives of patients with terminal cancer in French palliative care units: The Fami-Life multicenter cohort study - Archive ouverte HAL
Article Dans Une Revue Palliative and Supportive Care Année : 2023

Incidence and risk factors of prolonged grief in relatives of patients with terminal cancer in French palliative care units: The Fami-Life multicenter cohort study

Maité Garrouste-Orgeas
Véronique Marché
  • Fonction : Auteur
Nicolas Pujol
  • Fonction : Auteur
Dominique Michel
  • Fonction : Auteur
Adrien Evin
  • Fonction : Auteur
Virginie Fossez-Diaz
  • Fonction : Auteur
Ségolène Perruchio
  • Fonction : Auteur
Anne Vanbésien
  • Fonction : Auteur
Catherine Verlaine
  • Fonction : Auteur
Laure Copel
  • Fonction : Auteur
Willeme Kaczmarek
  • Fonction : Auteur
Véronique Michonneau-Gandon
  • Fonction : Auteur
Emmanuel de Larivière
  • Fonction : Auteur
Cécile Poupardin
  • Fonction : Auteur
Licia Touzet
  • Fonction : Auteur
Virginie Guastella
  • Fonction : Auteur
Carmen Mathias
  • Fonction : Auteur
Alaa Mhalla
  • Fonction : Auteur
Guillaume Bouquet
Bruno Richard
  • Fonction : Auteur
Dominique Gracia
  • Fonction : Auteur
Florent Bienfait
  • Fonction : Auteur
Virginie Verliac
  • Fonction : Auteur
Gaelle Ranchou
  • Fonction : Auteur
Sylvie Kirsch
  • Fonction : Auteur
Cécile Flahault
  • Fonction : Auteur
Ambre Loiodice
  • Fonction : Auteur
Stéphane Ruckly
  • Fonction : Auteur
Jean-François Timsit
  • Fonction : Auteur

Résumé

Abstract Objectives Psychological consequences of grief among relatives are insufficiently known. We reported incidence of prolonged grief among relatives of deceased patients with cancer. Methods Prospective cohort study of 611 relatives of 531 patients with cancer hospitalized for more than 72 hours and who died in 26 palliative care units was conducted. The primary outcome was prolonged grief in relatives 6 months after patient death, measured with the Inventory Complicated Grief (ICG > 25, range 0–76, a higher score indicates more severe symptoms) score. Secondary outcomes in relatives 6 months after patient death were anxiety and depression symptoms based on Hospital Anxiety and Depression Scale (HADS) score (range 0 [best]–42 [worst]), higher scores indicate more severe symptoms, minimally important difference 2.5. Post-traumatic stress disorder symptoms were defined by an Impact Event Scale-Revised score >22 (range 0–88, a higher score indicates more severe symptoms). Results Among 611 included relatives, 608 (99.5%) completed the trial. At 6 months, significant ICG scores were reported by 32.7% relatives (199/608, 95% CI, 29.0–36.4). The median (interquartile range ICG score) was 20.0 (11.5–29.0). The incidence of HADS symptoms was 87.5% (95% CI, 84.8–90.2%) at Days 3–5 and 68.7% (95% CI, 65.0–72.4) 6 months after patient’s death, with a median (interquartile range) difference of −4 (–10 to 0) between these 2 time points. Improvement in HADS anxiety and depression scores were reported by 62.5% (362/579) relatives. Significance of results These findings support the importance of screening relatives having risk factors of developing prolonged grief in the palliative unit and 6 months after patient’s death.

Dates et versions

hal-04658460 , version 1 (22-07-2024)

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Citer

Maité Garrouste-Orgeas, Véronique Marché, Nicolas Pujol, Dominique Michel, Adrien Evin, et al.. Incidence and risk factors of prolonged grief in relatives of patients with terminal cancer in French palliative care units: The Fami-Life multicenter cohort study. Palliative and Supportive Care, 2023, pp.1-10. ⟨10.1017/S1478951523000111⟩. ⟨hal-04658460⟩

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