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Poster De Conférence Année : 2024

Phytochemical exploration and biological evaluation of four Thymus L. species from Türkiye.

Résumé

Türkiye is rich in term of plant diversity with a high rate of endemism. Indeed, the country is shared between three biodiversity hotspots: Caucasus, Iran-Anatolia region and the Mediterranean basin (Noroozi et al. 2019). However, even if this richness translates into a high traditional use of plants for medicinal or cosmetic purposes, numerous of these plants remain unexplored in term of phytochemistry. Ethnobotanical studies revealed that Thymus L. species are used for cosmetic purposes. Thymus brachychilus Jalas, Thymus leucostomus Hausskn. & Velen., Thymus migricus Klokov & Des.-Shost., Thymus sipyleus Boiss. were obtained from different localities, turned into herbarium material and plant species were determined. To better understand their uses, metabolic activities of ethanolic extracts of these 4 species have been evaluated on Keratinocyte cells (HaCat) and Endothelial cells (HuVeC) while cytotoxicity have been evaluated on L929 fibroblast cells. The extracts didn’t show cytotoxicity and were ineffective on HaCat but demonstrated activation of HuVeC which can be promising for wound healing treatments. A phytochemical study of these extracts has been made by UHPLC-HRMS/MS. Data were represented using molecular networking and annotation tools as SIRIUS4 (Dührkop et al., 2019) and Tima-R (Rutz et al., 2019) were employed to increasing annotation confidence and to refine the compound identification. This methodology allowed us to identify main compounds of these extracts as triterpenoids, such as Uvaol, known for improving the functioning of endothelial cells (Carmo et al., 2020) and flavonoids, including polymethoxylated flavonoids, known for modulating endothelial cell functions (Lee et al., 2014)
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Dates et versions

hal-04654076 , version 1 (19-07-2024)

Identifiants

  • HAL Id : hal-04654076 , version 1

Citer

Pierre-Eric Campos, Audrey Le Cabec, Ebru Özdemir Nath, Sefa Sönmez, Gül İpek Gündoğan, et al.. Phytochemical exploration and biological evaluation of four Thymus L. species from Türkiye.. International Congress on Natural Products Research, Jul 2024, Krakow, Poland. ⟨hal-04654076⟩
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