Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides
Résumé
A convenient synthesis of a thymidine (T) nucleoside dimer (T-3′-CH2-O-NCH3-5′-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 3′-deoxy-3′-C-hydroxymethylthymidine is described. The new dimer and methodology is useful for the development of backbone-modified antisense oligonucleosides.
A convenient synthesis of a thymidine (T) nucleoside dimer (T-3′-CH2-O-NCH3-5′-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 2′,3′-dideoxy-3′-C-hydroxymethylthymidine is described. The new dimer and methodology is useful for the development of backbone modified antisense olignucleosides.
Domaines
Chimie
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Bioorganic & Medicinal Chemistry Letters 1992 Vol. 2 Pages 1479-1482 (1).pdf (351.77 Ko)
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