Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides - Archive ouverte HAL
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 1992

Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides

Francoise Debart
Jean-Jacques Vasseur
P. Dan Cook
  • Fonction : Auteur

Résumé

A convenient synthesis of a thymidine (T) nucleoside dimer (T-3′-CH2-O-NCH3-5′-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 3′-deoxy-3′-C-hydroxymethylthymidine is described. The new dimer and methodology is useful for the development of backbone-modified antisense oligonucleosides. A convenient synthesis of a thymidine (T) nucleoside dimer (T-3′-CH2-O-NCH3-5′-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 2′,3′-dideoxy-3′-C-hydroxymethylthymidine is described. The new dimer and methodology is useful for the development of backbone modified antisense olignucleosides.

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Chimie
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Dates et versions

hal-04651150 , version 1 (17-07-2024)

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Francoise Debart, Jean-Jacques Vasseur, Yogesh Sanghvi, P. Dan Cook. Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides. Bioorganic and Medicinal Chemistry Letters, 1992, 2 (12), pp.1479-1482. ⟨10.1016/S0960-894X(00)80412-6⟩. ⟨hal-04651150⟩
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