Intermolecular radical C-C bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides - Archive ouverte HAL
Article Dans Une Revue Tetrahedron Letters Année : 1992

Intermolecular radical C-C bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides

Francoise Debart
Jean-Jacques Vasseur
P. Dan Cook
  • Fonction : Auteur

Résumé

An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-Ch2NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides. An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.

Domaines

Chimie
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Dates et versions

hal-04651127 , version 1 (18-07-2024)

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Citer

Francoise Debart, Jean-Jacques Vasseur, Yogesh Sanghvi, P. Dan Cook. Intermolecular radical C-C bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides. Tetrahedron Letters, 1992, 33 (19), pp.2645-2648. ⟨10.1016/S0040-4039(00)79047-2⟩. ⟨hal-04651127⟩
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