Intermolecular radical C-C bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides
Résumé
An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-Ch2NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.
An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.
Domaines
Chimie
Fichier principal
Tetrahedron Letters 1992 Vol. 33 Pages 2645-2648 (1).pdf (269.16 Ko)
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