Alternative synthetic approaches for nucleotides and derivatives - Archive ouverte HAL
Article Dans Une Revue Phosphorus, Sulfur, and Silicon and the Related Elements Année : 2022

Alternative synthetic approaches for nucleotides and derivatives

Résumé

We have focused our attention on alternative synthetic approaches for nucleotides and dinucleotides, that simplifies purification and/or improves sustainability. On one hand, we developed a liquid-phase synthesis using a benzene-centred tripodal support to prepare adenine nucleoside phosphoesters and methylenebisphosphonate derivatives. On the other hand, we used mechanochemistry, a technique that enables solid/solid reactions through mechanical grinding under solventless or solvent-free conditions, to get access to dinucleotides.
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hal-04649441 , version 1 (16-07-2024)

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Lucie Appy, Anaïs Depaix, Xavier Bantreil, Frédéric Lamaty, Suzanne Peyrottes, et al.. Alternative synthetic approaches for nucleotides and derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements, 2022, 197 (5-6), pp.434-437. ⟨10.1080/10426507.2021.1998050⟩. ⟨hal-04649441⟩
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