Water-soluble NHC Pd/Ni bimetallic nanoparticles for H/D exchange in aromatic amino-acids
Résumé
Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an enantiospecific fashion without reducing the aromatic ring of phenylalanine and tyrosine thanks to a synergetic Pd–Ni effect.
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