Isolation, NMR Characterization, and Bioactivity of a Flavonoid Triglycoside from Anthyllis henoniana Stems: Antioxidant and Antiproliferative Effects on MDA-MB-231 Breast Cancer Cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Antioxidants Année : 2024

Isolation, NMR Characterization, and Bioactivity of a Flavonoid Triglycoside from Anthyllis henoniana Stems: Antioxidant and Antiproliferative Effects on MDA-MB-231 Breast Cancer Cells

Amani Ayachi
  • Fonction : Auteur
Guillaume Boy
Sonda Samet
  • Fonction : Auteur
Bouthaina Bouzayani
  • Fonction : Auteur
Michel Treilhou
  • Fonction : Auteur
Raoudha Mezghani-Jarraya
  • Fonction : Auteur

Résumé

Plant extracts are considered as a large source of active biomolecules, especially in phytosanitary and pharmacological fields. Anthyllis henoniana is a woody Saharan plant located in the big desert of North Africa. Our previous research paper proved the richness of the methanol extract obtained from the stems in flavonoids and phenolic compounds as well as its remarkable antioxidant activity. In this research, we started by investigating the phytochemical composition of the methanol extract using high performance liquid chromatography coupled with electrospray ionization mass spectrometry (LC–MS/MS). Among the 41 compounds identified, we isolated and characterized (structurally and functionally) the most abundant product, a flavonoid triglycoside (AA770) not previously described in this species. This compound, which presents no cytotoxic activity, exhibits an interesting cellular antioxidant effect by reducing reactive oxygen species (ROS) generation, and an antiproliferative action on breast cancer cells. This study provides a preliminary investigation into the pharmacological potential of the natural compound AA770, isolated and identified from Anthyllis henoniana for the first time.

Dates et versions

hal-04635159 , version 1 (04-07-2024)

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Citer

Amani Ayachi, Guillaume Boy, Sonda Samet, Nathan Téné, Bouthaina Bouzayani, et al.. Isolation, NMR Characterization, and Bioactivity of a Flavonoid Triglycoside from Anthyllis henoniana Stems: Antioxidant and Antiproliferative Effects on MDA-MB-231 Breast Cancer Cells. Antioxidants , 2024, 13 (7), pp.793. ⟨10.3390/antiox13070793⟩. ⟨hal-04635159⟩

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