Investigation of Ln 3+ complexation by a DOTA derivative substituted by an imidazothiadiazole: synthesis, solution structure, luminescence and relaxation properties - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Dalton Transactions Année : 2024

Investigation of Ln 3+ complexation by a DOTA derivative substituted by an imidazothiadiazole: synthesis, solution structure, luminescence and relaxation properties

Résumé

We investigated the coordination properties of original macrocyclic Ln(3+) complexes comprising an imidazothiadiazole heterocycle. The thermodynamic stability of the Gd3+ complex was determined by a combination of potentiometric and photophysical measurements. The kinetic inertness was assessed in highly acidic media. The solution structure of the Ln(3+) complex was unambiguously determined by a set of photophysical measurements and H-1, C-13, Y-89 NMR data in combination with DFT calculations, which proved coordination of the heterocycle to Ln(3+). The ability of the imidazothiadiazole moiety to sensitize Tb3+ luminescence was investigated. Finally, the relaxation properties were investigated by recording H-1 nuclear magnetic relaxation dispersion (NMRD) profiles and O-17 measurements. The water exchange rate is similar to that of GdDOTA as the less negative charge of the ligand is compensated for by the presence of a bulky heterocycle. Relaxivity is constant over a large range of pH values, demonstrating the favorable properties of the complex for imaging purposes.
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Dates et versions

hal-04634319 , version 1 (03-07-2024)

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Emma Caillet, Léa Nunes, Svetlana Eliseeva, Modou Ndiaye, Manon Isaac, et al.. Investigation of Ln 3+ complexation by a DOTA derivative substituted by an imidazothiadiazole: synthesis, solution structure, luminescence and relaxation properties. Dalton Transactions, 2024, 53 (21), pp.9028-9041. ⟨10.1039/d4dt00533c⟩. ⟨hal-04634319⟩
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