Measuring the Efficiency of Purging by non-random Mating in Human Populations
Résumé
Human populations harbor a high concentration of deleterious genetic variants. Here, we tested the hypothesis that non-random mating practices affect the distribution of these variants, through exposure in the homozygous state, leading to their purging from the population gene pool. To do so, we produced whole-genome sequencing data for two pairs of Asian populations exhibiting different alliance rules and rates of inbreeding, but with similar effective population sizes. The results show that populations with higher rates of inbred matings do not purge deleterious variants more efficiently. Purging therefore has a low efficiency in human populations, and different mating practices lead to a similar mutational load.
Mots clés
Purifying selection
Kinship
Mate choice
Inbreeding
Genomics analyses
Deleterious variants
Mutational analysis
Purging
Non-random mating
Homozygous variants
Population genetics
Whole-genome sequencing
Inbred populations
Nucleotide Transport Proteins
Molecular evolution
Artificial and natural selection
bioinformatics
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