Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomaterials Science Année : 2023

Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Résumé

Nanoplatforms with amplified passive tumor targeting and enhanced protein resistance can evade unnecessary uptake by the reticuloendothelial system and achieve high tumor retention for accurate tumor theranostics. To achieve this goal, we here constructed phosphorus core–shell tecto dendrimers (CSTDs) with a rigid aromatic backbone core as a nanoplatform for enhanced fluorescence and single-photon emission computed tomography (SPECT) dual-mode imaging of tumors. In this study, the phosphorus P-G2.5/G3 CSTDs (G denotes generation) were partially conjugated with tetraazacyclododecane tetraacetic acid (DOTA), cyanine5.5 (Cy5.5) and 1,3-propane sulfonate (1,3-PS) and then labeled with 99mTc. The formed P-G2.5/G3-DOTA-Cy5.5-PS CSTDs possess good monodispersity with a particle size of 10.1 nm and desired protein resistance and cytocompatibility. Strikingly, compared to the counterpart material G3/G3-DOTA-Cy5.5-PS with both the core and shell components being soft poly(amidoamine) dendrimers, the developed P-G2.5/G3-DOTA-Cy5.5-PS complexes allow for more efficient cellular uptake and more significant penetration in 3-dimensional tumor spheroids in vitro, as well as more significant tumor retention and accumulation for enhanced dual-mode fluorescence and SPECT (after labelling with 99mTc) tumor imaging in vivo. Our studies suggest that the rigidity of the core for the constructed CSTDs matters in the amplification of the tumor enhanced permeability retention (EPR) effect for improved cancer nanomedicine development.

Domaines

Cancer
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Dates et versions

hal-04632450 , version 1 (02-07-2024)

Identifiants

Citer

Mengsi Zhan, Dayuan Wang, Lingzhou Zhao, Liang Chen, Zhijun Ouyang, et al.. Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters. Biomaterials Science, 2023, 11 (22), pp.7387-7396. ⟨10.1039/D3BM01198D⟩. ⟨hal-04632450⟩
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