Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort
Tahir Taj
(1)
,
Jie Chen
(2)
,
Sophia Rodopoulou
(3)
,
Maciej Strak
(2, 4)
,
Kees de Hoogh
(5, 6)
,
Aslak Harbo Poulsen
(1)
,
Zorana J. Andersen
(7)
,
Tom Bellander
(8)
,
Jørgen Brandt
(9)
,
Emanuel Zitt
(10)
,
Daniela Fecht
(11)
,
Francesco Forastiere
(11, 12)
,
John Gulliver
(11, 13)
,
Ole Hertel
(9)
,
Barbara Hoffmann
(14)
,
Ulla Arthur Hvidtfeldt
(1)
,
Jeanette T. Jørgensen
(7)
,
Klea Katsouyanni
(11, 3)
,
Matthias Ketzel
(9, 15)
,
Anton Lager
(8)
,
Karin Leander
(8)
,
Shuo Liu
(7)
,
Petter Ljungman
(8)
,
Gianluca Severi
(16, 17, 18)
,
Caroline Besson
(16)
,
Patrik K.E. Magnusson
(8)
,
Gabriele Nagel
(19, 20)
,
Göran Pershagen
(8)
,
Annette Peters
(21)
,
Debora Rizzuto
(8, 22)
,
Evangelia Samoli
(3)
,
Mette Sørensen
(23, 1)
,
Massimo Stafoggia
(8)
,
Anne Tjønneland
(1)
,
Gudrun Weinmayr
(19)
,
Kathrin Wolf
(21)
,
Bert Brunekreef
(2)
,
Gerard Hoek
(2)
,
Ole Raaschou-Nielsen
(1, 9)
1
Danish Cancer Society
2 Universiteit Utrecht / Utrecht University [Utrecht]
3 NKUA - National and Kapodistrian University of Athens
4 RIVM - National Institute for Public Health and the Environment [Bilthoven]
5 Unibas - Université de Bâle = University of Basel = Basel Universität
6 Swiss Tropical and Public Health Institute [Basel]
7 UCPH - University of Copenhagen = Københavns Universitet
8 Karolinska Institutet [Stockholm]
9 Aarhus University [Aarhus]
10 Universitäres Lehrkrankenhaus Feldkirch
11 Imperial College London
12 Department of Epidemiology, Lazio Regional Health Service
13 University of Leicester
14 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
15 UNIS - University of Surrey
16 CESP - Centre de recherche en épidémiologie et santé des populations
17 IGR - Institut Gustave Roussy
18 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
19 Universität Ulm - Ulm University [Ulm, Allemagne]
20 Institute of Epidemiology and Medical Biometry [Ulm, Allemagne]
21 IBB - Institute of Biomathematics and Biometry - Helmholtz Zentrum München
22 Stockholm University
23 Roskilde Universitet [Roskilde]
2 Universiteit Utrecht / Utrecht University [Utrecht]
3 NKUA - National and Kapodistrian University of Athens
4 RIVM - National Institute for Public Health and the Environment [Bilthoven]
5 Unibas - Université de Bâle = University of Basel = Basel Universität
6 Swiss Tropical and Public Health Institute [Basel]
7 UCPH - University of Copenhagen = Københavns Universitet
8 Karolinska Institutet [Stockholm]
9 Aarhus University [Aarhus]
10 Universitäres Lehrkrankenhaus Feldkirch
11 Imperial College London
12 Department of Epidemiology, Lazio Regional Health Service
13 University of Leicester
14 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
15 UNIS - University of Surrey
16 CESP - Centre de recherche en épidémiologie et santé des populations
17 IGR - Institut Gustave Roussy
18 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
19 Universität Ulm - Ulm University [Ulm, Allemagne]
20 Institute of Epidemiology and Medical Biometry [Ulm, Allemagne]
21 IBB - Institute of Biomathematics and Biometry - Helmholtz Zentrum München
22 Stockholm University
23 Roskilde Universitet [Roskilde]
Jie Chen
- Fonction : Auteur
- PersonId : 1343457
- ORCID : 0000-0001-9644-8026
Kees de Hoogh
- Fonction : Auteur
- PersonId : 1343458
- ORCID : 0000-0001-5974-2007
Aslak Harbo Poulsen
- Fonction : Auteur
- PersonId : 1163586
- ORCID : 0000-0003-4456-4169
Tom Bellander
- Fonction : Auteur
- PersonId : 1395918
- ORCID : 0000-0001-7336-4161
Jørgen Brandt
- Fonction : Auteur
- PersonId : 805532
- ORCID : 0000-0002-7580-9547
Emanuel Zitt
- Fonction : Auteur
- PersonId : 1395924
- ORCID : 0000-0001-6944-6041
Ole Hertel
- Fonction : Auteur
- PersonId : 1395922
- ORCID : 0000-0003-0972-7735
Barbara Hoffmann
- Fonction : Auteur
- PersonId : 1222644
- ORCID : 0000-0002-8435-5575
Ulla Arthur Hvidtfeldt
- Fonction : Auteur
- PersonId : 805530
- ORCID : 0000-0002-0335-4838
Klea Katsouyanni
- Fonction : Auteur
- PersonId : 1395947
- ORCID : 0000-0002-0132-9575
Karin Leander
- Fonction : Auteur
- PersonId : 773564
- ORCID : 0000-0002-1404-9222
Caroline Besson
- Fonction : Auteur
- PersonId : 758397
- ORCID : 0000-0003-4364-7173
- IdRef : 096287608
Annette Peters
- Fonction : Auteur
- PersonId : 764072
- ORCID : 0000-0001-6645-0985
Debora Rizzuto
- Fonction : Auteur
- PersonId : 1395923
- ORCID : 0000-0001-6199-9629
Evangelia Samoli
- Fonction : Auteur
- PersonId : 1218007
- ORCID : 0000-0002-9266-9929
Mette Sørensen
- Fonction : Auteur
- PersonId : 809305
- ORCID : 0000-0002-7302-4789
Kathrin Wolf
- Fonction : Auteur
- PersonId : 1343460
- ORCID : 0000-0002-4343-201X
Ole Raaschou-Nielsen
- Fonction : Auteur
- PersonId : 760921
- ORCID : 0000-0002-1223-0909
Résumé
Leukemia and lymphoma are the two most common forms of hematologic malignancy, and their etiology is largely unknown. Pathophysiological mechanisms suggest a possible association with air pollution, but little empirical evidence is available. We aimed to investigate the association between long-term residential exposure to outdoor air pollution and risk of leukemia and lymphoma. We pooled data from four cohorts from three European countries as part of the u201cEffects of Low-level Air Pollution: a Study in Europeu201d (ELAPSE) collaboration. We used Europe-wide land use regression models to assess annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone (O3) at residences. We also estimated concentrations of PM2.5 elemental components: copper (Cu), iron (Fe), zinc (Zn); sulfur (S); nickel (Ni), vanadium (V), silicon (Si) and potassium (K). We applied Cox proportional hazards models to investigate the associations. Among the study population of 247,436 individuals, 760 leukemia and 1122 lymphoma cases were diagnosed during 4,656,140 person-years of follow-up. The results showed a leukemia hazard ratio (HR) of 1.13 (95% confidence intervals [CI]: 1.01u20131.26) per 10 μg/m3 NO2, which was robust in two-pollutant models and consistent across the four cohorts and according to smoking status. Sex-specific analyses suggested that this association was confined to the male population. Further, the results showed increased lymphoma HRs for PM2.5 (HR = 1.16; 95% CI: 1.02u20131.34) and potassium content of PM2.5, which were consistent in two-pollutant models and according to sex. Our results suggest that air pollution at the residence may be associated with adult leukemia and lymphoma.