Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Pharmacology Année : 2021

Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations

Résumé

Abstract Population pharmacokinetics consists of analyzing pharmacokinetic (PK) data collected in groups of individuals. Population PK is widely used to guide drug development and to inform dose adjustment via therapeutic drug monitoring and model‐informed precision dosing. There are 2 main types of population PK methods: parametric (P) and nonparametric (NP). The characteristics of P and NP population methods have been previously reviewed. The aim of this article is to answer some frequently asked questions that are often raised by scholars, clinicians, and researchers about P and NP population PK methods. The strengths and limitations of both approaches are explained, and the characteristics of the main software programs are presented. We also review the results of studies that compared the results of both approaches in the analysis of real data. This opinion article may be informative for potential users of population methods in PK and guide them in the selection and use of those tools. It also provides insights on future research in this area.
Fichier non déposé

Dates et versions

hal-04626734 , version 1 (27-06-2024)

Identifiants

Citer

Sylvain Goutelle, Jean-Baptiste Woillard, Thierry Buclin, Laurent Bourguignon, Walter Yamada, et al.. Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations. Journal of Clinical Pharmacology, 2021, 62 (2), pp.158-170. ⟨10.1002/jcph.1993⟩. ⟨hal-04626734⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More