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Software Year : 2024

Norine

Abstract

Norine (https://norine.univ-lille.fr/norine) is the unique resource dedicated to computational biology analysis of nonribosomal peptides (NRPs) that represent a huge reservoir of microbial secondary metabolites with applications in human, animal, and environmental health. First released in 2006 [1], this resource is composed of a database together with tools useful for NRP analysis including visualization and structure comparison. A specificity of the database is that it can be queried according to both annotation and peptide structures. This project results from a University Lille (France) collaboration between computer science researchers from CRIStAL (Centre de Recherche en Informatique et Automatique de Lille) and microbiologists from ICV (Charles Viollette Institute) and BioEcoAgro crossborder joint research unit. In 2015, Norine was opened to communinity of biologists and bio-chemists in order to enrich the database thanks to the MyNorine tool [2]. A workflow and strict manual validation of annotations ensure high quality of data in Norine database. In 2020, Norine was labelized ELIXIR-FR Service Delivery Plan (SDP) through the French node IFB (Institut Français de Bioinformatique) and registered on bio.tools (https://bio.tools/NORINE). And in 2022, the Norine project received the Open Science Research Data Award 2022 by the French Ministry of Higher Education and Research. [1] Ségolène Caboche, Maude Pupin, Valérie Leclère, Arnaud Fontaine, Philippe Jacques, Gregory Kucherov, NORINE: a database of nonribosomal peptides, Nucleic Acids Research, Volume 36, Issue suppl_1, 1 January 2008, Pages D326–D331, https://doi.org/10.1093/nar/gkm792 [2] Areski Flissi, Yoann Dufresne, Juraj Michalik, Laurie Tonon, Stéphane Janot, Laurent Noé, Philippe Jacques, Valérie Leclère, Maude Pupin, Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing, Nucleic Acids Research, Volume 44, Issue D1, 4 January 2016, Pages D1113–D1118, https://doi.org/10.1093/nar/gkv1143
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