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Article Dans Une Revue (Article De Synthèse) Neuro-Oncology Année : 2024

Radioligand therapies in meningioma – evidence and future directions

Résumé

Meningiomas are the most common intracranial neoplasms in adults. While most meningiomas are cured by resection, further treatment by radiotherapy may be needed, particularly in WHO grade 2 and 3 tumors which have an increased risk of recurrence, even after conventional therapies. Still, there is an urgent need for novel therapeutic strategies after exhaustion of local treatment approaches. Radionuclide therapies combine the specificity of tumor-specific antibodies or ligands with the cytotoxic activity of radioactive emitters. Alongside, integrated molecular imaging allows for a non-invasive assessment of predictive biomarkers as treatment targets. Whereas the concept of “theranostics” has initially evolved in extracranial tumors such as thyroid diseases, neuroendocrine tumors, and prostate cancer, data from retrospective case series and early phase trials underscore the potential of this strategy in meningioma. This review aims to explore the available evidence of radionuclide treatments and ongoing clinical trial initiatives in meningioma. Moreover, we discuss optimal clinical trial design and future perspectives in the field, including compound- and host-specific determinants of the efficacy of “theranostic” treatment approaches.
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Dates et versions

hal-04615780 , version 1 (03-07-2024)

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Maximilian Mair, Emeline Tabouret, Derek Johnson, Erik Sulman, Patrick Wen, et al.. Radioligand therapies in meningioma – evidence and future directions. Neuro-Oncology, 2024, ⟨10.1093/neuonc/noae069⟩. ⟨hal-04615780⟩
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