Random survival forests for the analysis of recurrent events for right-censored data, with or without a terminal event - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2024

Random survival forests for the analysis of recurrent events for right-censored data, with or without a terminal event

Résumé

Random survival forests (RSF) have emerged as valuable tools in medical research. They have shown their utility in modelling complex relationships between predictors and survival outcomes, overcoming linearity or low dimensionality assumptions. Nevertheless, RSF have not been adapted to right-censored data with recurrent events (RE). This work introduces RecForest, an extension of RSF and tailored for RE data, leveraging principles from survival analysis and ensemble learning. RecForest adapts the splitting rule to account for RE, with or without a terminal event, by employing the pseudo-score test or the Wald test derived from the marginal Ghosh-Lin model. The ensemble estimate is constructed by aggregating the expected number of events from each tree. Performance metrics involve a concordance index (C-index) tailored for RE analysis, along with an extension of the mean squared error (MSE). A comprehensive evaluation was conducted on both simulated and open-source data. We compared RecForest against the non-parametric mean cumulative function and the Ghosh-Lin model. Across the simulations and application, RecForest consistently outperforms, exhibiting C-index values ranging from 0.64 to 0.80 and lowest MSE metrics. As analysing time-to-recurrence data is critical in medical research, the proposed method represents a valuable addition to the analytical toolbox in this domain.
Fichier principal
Vignette du fichier
preprint_recforest.pdf (1.13 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04612431 , version 1 (14-06-2024)

Identifiants

  • HAL Id : hal-04612431 , version 1

Citer

Juliette Murris, Olivier Bouaziz, Michal Jakubczak, Sandrine Katsahian, Audrey Lavenu. Random survival forests for the analysis of recurrent events for right-censored data, with or without a terminal event. 2024. ⟨hal-04612431⟩
0 Consultations
0 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More