Attitudes towards deprescribing among proton pomp inhibitors chronic users
Résumé
Background: Deprescribing proton pump inhibitors (PPI) is recommended when itsuse is considered inappropriate. Patients' beliefs and perceptions of deprescribing shouldbe explored to target patients who are potentially willing to reduce or stop their PPI use.Objective: The objective of this study was to assess the attitudes toward deprescribingamong PPI chronic users in the French setting.Methods: This is an ancillary study of a pragmatic trial conducted on adults having over300 defined daily doses of PPI dispensed in the year before inclusion. One month beforethe start of this trial, we mailed the French version of the revised Patients’ AttitudeToward Deprescribing questionnaire (rPATD) to a 10% sample. We used descriptiveanalysis to depict the characteristics of the respondents. We used multivariate analysis toexplore associations between characteristics and answers to the rPATD.Results: A total of 1861 questionnaires were collected among 3554 targeted patients(52.4% response-rate). The mean age was 76.6 years (SD 7.8), 55% were female, 63%had at least one chronic condition. Among the responders, 75% reported being satisfiedwith their current medicines although 91% reported that they would be willing to stop atleast one of their current medications if their doctor said it was possible. Answersresulted in a high involvement factor score (mean = 4.4; SD 0.9) and a lowappropriateness factor score (mean = 1.9; SD 1.1). Male sex (p = .016) and having adoctor working in a group practice (p = .010) were the characteristics significantlyassociated with a willingness to deprescribe at least one medication.Conclusion: Most PPI chronic users are willing to deprescribe at least one of theircurrent medications. These findings and upcoming results of our deprescribing trialshould address whether the rPATD can predict the success of a deprescribingintervention.