Enterocin DD14 can inhibit the infection of eukaryotic cells with enveloped viruses - Archive ouverte HAL
Article Dans Une Revue Archives of Microbiology Année : 2024

Enterocin DD14 can inhibit the infection of eukaryotic cells with enveloped viruses

Famara Sane

Résumé

Bacteriocins are ribosomally synthesized bacterial peptides endowed with antibacterial, antiprotozoal, anticancer and antiviral activities. In the present study, we evaluated the antiviral activities of two bacteriocins, enterocin DD14 (EntDD14) and lacticaseicin 30, against herpes simplex virus type 1 (HSV-1), human coronavirus 229E (HCoV-229E) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero, Huh7 and Vero E6 cells, respectively. In addition, the interactions of these bacteriocins with the envelope glycoprotein D of HSV-1 and the receptor binding domains of HCoV-229E and SARS-CoV-2 have been computationally evaluated using protein-protein docking and molecular dynamics simulations. HSV-1 replication in Vero cells was inhibited by EntDD14 and, to a lesser extent, by lacticaseicin 30 added to cells after virus inoculation. EntDD14 and lacticaseicin 30 had no apparent antiviral activity against HCoV-229E; however, EntDD14 was able to inhibit SARS-CoV-2 in Vero E6 cells. Further studies are needed to elucidate the antiviral mechanism of these bacteriocins.
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Dates et versions

hal-04606993 , version 1 (10-06-2024)

Identifiants

Citer

Radja Teiar, Famara Sane, Ismail Erol, Magloire Pandoua Nekoua, Didier Lecouturier, et al.. Enterocin DD14 can inhibit the infection of eukaryotic cells with enveloped viruses. Archives of Microbiology, 2024, 206 (269), pp.269. ⟨10.1007/s00203-024-04002-7⟩. ⟨hal-04606993⟩
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