Extraction Techniques and Analytical Methods for Isolation and Characterization of Lignans - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Plants Année : 2022

Extraction Techniques and Analytical Methods for Isolation and Characterization of Lignans

Résumé

Lignans are a group of natural polyphenols present in medicinal plants and in plants which are a part of the human diet for which more and more pharmacological activities, such as antimicrobial, anti-inflammatory, hypoglycemic, and cytoprotective, are being reported. However, it is their cytotoxic activities that are best understood and which have shed light on this group. Two anticancer drugs, etoposide, and teniposide, were derived from a potent cytotoxic agent—podophyllotoxin from the roots of Podophyllum peltatum. The evidence from clinical and observational studies suggests that human microbiota metabolites (enterolactone, enterodiol) of dietary lignans (secoisolariciresinol, pinoresinol, lariciresinol, matairesinol, syringaresinol, medioresinol, and sesamin) are associated with a reduced risk of some hormone-dependent cancers. The biological in vitro, pharmacological in vivo investigations, and clinical studies demand significant amounts of pure compounds, as well as the use of well-defined and standardized extracts. That is why proper extract preparation, optimization of lignan extraction, and identification are crucial steps in the development of lignan use in medicine. This review focuses on lignan extraction, purification, fractionation, separation, and isolation methods, as well as on chromatographic, spectrometric, and spectroscopic techniques for their qualitative and quantitative analysis.

Mots clés

Fichier principal
Vignette du fichier
Extraction Techniques and Analytical Methods for Isolation and Characterization of Lignans.pdf (690.84 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04605679 , version 1 (07-06-2024)

Licence

Identifiants

Citer

Andrzej Patyra, Małgorzata Kołtun-Jasion, Oktawia Jakubiak, Anna Karolina Kiss. Extraction Techniques and Analytical Methods for Isolation and Characterization of Lignans. Plants, 2022, 11 (17), pp.2323. ⟨10.3390/plants11172323⟩. ⟨hal-04605679⟩
4 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More