<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04602386</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T16:29:14+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Machine learning-based health environmental-clinical risk scores in European children</title>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Baptiste</forename>
                <surname>Guimbaud</surname>
              </persName>
              <email type="md5">3c1bd3cc458d596b2da27d4f7f555910</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">jean-baptiste-guimbaud</idno>
              <idno type="idhal" notation="numeric">1168132</idno>
              <idno type="halauthorid" notation="string">2593519-1168132</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3748-1453</idno>
              <affiliation ref="#struct-413086"/>
              <affiliation ref="#struct-533869"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandros</forename>
                <surname>Siskos</surname>
              </persName>
              <idno type="idhal" notation="numeric">808412</idno>
              <idno type="halauthorid" notation="string">2175234-808412</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5635-7426</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amrit Kaur</forename>
                <surname>Sakhi</surname>
              </persName>
              <idno type="halauthorid">2176815-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Barbara</forename>
                <surname>Heude</surname>
              </persName>
              <idno type="halauthorid">153656-0</idno>
              <affiliation ref="#struct-1002409"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eduard</forename>
                <surname>Sabidó</surname>
              </persName>
              <idno type="halauthorid">2175258-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eva</forename>
                <surname>Borràs</surname>
              </persName>
              <idno type="halauthorid">2175257-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hector</forename>
                <surname>Keun</surname>
              </persName>
              <idno type="halauthorid">2175235-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">John</forename>
                <surname>Wright</surname>
              </persName>
              <idno type="halauthorid">742644-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jordi</forename>
                <surname>Julvez</surname>
              </persName>
              <idno type="halauthorid">1415511-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jose</forename>
                <surname>Urquiza</surname>
              </persName>
              <idno type="idhal" notation="numeric">1320498</idno>
              <idno type="halauthorid" notation="string">1486247-1320498</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2220-607X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kristine Bjerve</forename>
                <surname>Gützkow</surname>
              </persName>
              <idno type="halauthorid">3167666-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Leda</forename>
                <surname>Chatzi</surname>
              </persName>
              <idno type="halauthorid">859580-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maribel</forename>
                <surname>Casas</surname>
              </persName>
              <idno type="halauthorid">465732-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mariona</forename>
                <surname>Bustamante</surname>
              </persName>
              <idno type="idhal" notation="numeric">791009</idno>
              <idno type="halauthorid" notation="string">1342256-791009</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0127-2860</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mark</forename>
                <surname>Nieuwenhuijsen</surname>
              </persName>
              <idno type="halauthorid">307176-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Martine</forename>
                <surname>Vrijheid</surname>
              </persName>
              <idno type="halauthorid">529374-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mónica</forename>
                <surname>López-Vicente</surname>
              </persName>
              <idno type="idhal" notation="numeric">1389550</idno>
              <idno type="halauthorid" notation="string">2257100-1389550</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5090-7538</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Montserrat</forename>
                <surname>de Castro Pascual</surname>
              </persName>
              <idno type="idhal" notation="numeric">1308558</idno>
              <idno type="halauthorid" notation="string">3167667-1308558</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6547-5953</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nikos</forename>
                <surname>Stratakis</surname>
              </persName>
              <idno type="halauthorid">2264060-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Oliver</forename>
                <surname>Robinson</surname>
              </persName>
              <idno type="halauthorid">1799020-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Regina</forename>
                <surname>Grazuleviciene</surname>
              </persName>
              <idno type="halauthorid">480659-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Remy</forename>
                <surname>Slama</surname>
              </persName>
              <idno type="halauthorid">1169216-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Silvia</forename>
                <surname>Alemany</surname>
              </persName>
              <idno type="idhal" notation="numeric">818637</idno>
              <idno type="halauthorid" notation="string">2375536-818637</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7925-6767</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <surname>Basagaña</surname>
              </persName>
              <email type="md5">c1fe14559c26d6e84c5e9003a0f6e1f1</email>
              <email type="domain">isglobal.org</email>
              <idno type="idhal" notation="numeric">767899</idno>
              <idno type="halauthorid" notation="string">534028-767899</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8457-1489</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Plantevit</surname>
              </persName>
              <email type="md5">adc31f6425ef95bd13b73a6fa3cde904</email>
              <email type="domain">liris.cnrs.fr</email>
              <idno type="idhal" notation="string">marc-plantevit</idno>
              <idno type="idhal" notation="numeric">2640</idno>
              <idno type="halauthorid" notation="string">11402-2640</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4636-5753</idno>
              <idno type="IDREF">https://www.idref.fr/125705328</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rémy</forename>
                <surname>Cazabet</surname>
              </persName>
              <email type="md5">e4b9572fb4b7fb9f215b8f6561a15b85</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">remy-cazabet</idno>
              <idno type="idhal" notation="numeric">15745</idno>
              <idno type="halauthorid" notation="string">19315-15745</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9429-3865</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=ZPeN_HAAAAAJ&amp;hl=en&amp;oi=ao</idno>
              <idno type="IDREF">https://www.idref.fr/176017674</idno>
              <affiliation ref="#struct-413086"/>
              <affiliation ref="#struct-2003"/>
              <affiliation ref="#struct-194495"/>
              <affiliation ref="#struct-145352"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Léa</forename>
                <surname>Maitre</surname>
              </persName>
              <idno type="halauthorid">1799021-0</idno>
              <affiliation ref="#struct-533869"/>
              <affiliation ref="#struct-128785"/>
              <affiliation ref="#struct-301929"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jean-Baptiste</forename>
                <surname>Guimbaud</surname>
              </persName>
              <email type="md5">3c1bd3cc458d596b2da27d4f7f555910</email>
              <email type="domain">gmail.com</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-06-05 16:19:51</date>
              <date type="whenModified">2026-03-23 18:24:35</date>
              <date type="whenReleased">2024-06-05 16:19:51</date>
              <date type="whenProduced">2024-05-23</date>
              <ref type="externalLink" target="https://www.nature.com/articles/s43856-024-00513-y.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1047219">
                <persName>
                  <forename>Jean-Baptiste</forename>
                  <surname>Guimbaud</surname>
                </persName>
                <email type="md5">3c1bd3cc458d596b2da27d4f7f555910</email>
                <email type="domain">gmail.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04602386</idno>
            <idno type="halUri">https://hal.science/hal-04602386</idno>
            <idno type="halBibtex">guimbaud:hal-04602386</idno>
            <idno type="halRefHtml">&lt;i&gt;Communications Medicine&lt;/i&gt;, 2024, 4 (1), pp.98. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s43856-024-00513-y"&gt;&amp;#x27E8;10.1038/s43856-024-00513-y&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Communications Medicine, 2024, 4 (1), pp.98. &amp;#x27E8;10.1038/s43856-024-00513-y&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="ENS-LYON">École Normale Supérieure de Lyon</idno>
            <idno type="stamp" n="UNIV-LYON3">Université Jean Moulin - Lyon III</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="UNIV-LYON2">Université Lumière Lyon 2</idno>
            <idno type="stamp" n="INSA-LYON">Institut National des Sciences Appliquées de Lyon</idno>
            <idno type="stamp" n="EC-LYON">Ecole Centrale de Lyon</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="LIRIS" corresp="UNIV-LYON1">Laboratoire d'InfoRmatique en Image et Systèmes d'information</idno>
            <idno type="stamp" n="LYON2">Université Lyon2</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="CRESS">Centre de recherche en épidémiologie et statistiques</idno>
            <idno type="stamp" n="HAL-LYON-2-NOUVELLE-VERSION">Nouvelle version portail </idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Machine learning-based health environmental-clinical risk scores in European children</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Baptiste</forename>
                    <surname>Guimbaud</surname>
                  </persName>
                  <email type="md5">3c1bd3cc458d596b2da27d4f7f555910</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">jean-baptiste-guimbaud</idno>
                  <idno type="idhal" notation="numeric">1168132</idno>
                  <idno type="halauthorid" notation="string">2593519-1168132</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3748-1453</idno>
                  <affiliation ref="#struct-413086"/>
                  <affiliation ref="#struct-533869"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandros</forename>
                    <surname>Siskos</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">808412</idno>
                  <idno type="halauthorid" notation="string">2175234-808412</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5635-7426</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amrit Kaur</forename>
                    <surname>Sakhi</surname>
                  </persName>
                  <idno type="halauthorid">2176815-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Barbara</forename>
                    <surname>Heude</surname>
                  </persName>
                  <idno type="halauthorid">153656-0</idno>
                  <affiliation ref="#struct-1002409"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eduard</forename>
                    <surname>Sabidó</surname>
                  </persName>
                  <idno type="halauthorid">2175258-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eva</forename>
                    <surname>Borràs</surname>
                  </persName>
                  <idno type="halauthorid">2175257-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hector</forename>
                    <surname>Keun</surname>
                  </persName>
                  <idno type="halauthorid">2175235-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">John</forename>
                    <surname>Wright</surname>
                  </persName>
                  <idno type="halauthorid">742644-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jordi</forename>
                    <surname>Julvez</surname>
                  </persName>
                  <idno type="halauthorid">1415511-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jose</forename>
                    <surname>Urquiza</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1320498</idno>
                  <idno type="halauthorid" notation="string">1486247-1320498</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2220-607X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kristine Bjerve</forename>
                    <surname>Gützkow</surname>
                  </persName>
                  <idno type="halauthorid">3167666-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Leda</forename>
                    <surname>Chatzi</surname>
                  </persName>
                  <idno type="halauthorid">859580-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maribel</forename>
                    <surname>Casas</surname>
                  </persName>
                  <idno type="halauthorid">465732-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mariona</forename>
                    <surname>Bustamante</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">791009</idno>
                  <idno type="halauthorid" notation="string">1342256-791009</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0127-2860</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mark</forename>
                    <surname>Nieuwenhuijsen</surname>
                  </persName>
                  <idno type="halauthorid">307176-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Martine</forename>
                    <surname>Vrijheid</surname>
                  </persName>
                  <idno type="halauthorid">529374-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mónica</forename>
                    <surname>López-Vicente</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1389550</idno>
                  <idno type="halauthorid" notation="string">2257100-1389550</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5090-7538</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Montserrat</forename>
                    <surname>de Castro Pascual</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1308558</idno>
                  <idno type="halauthorid" notation="string">3167667-1308558</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6547-5953</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nikos</forename>
                    <surname>Stratakis</surname>
                  </persName>
                  <idno type="halauthorid">2264060-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Oliver</forename>
                    <surname>Robinson</surname>
                  </persName>
                  <idno type="halauthorid">1799020-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Regina</forename>
                    <surname>Grazuleviciene</surname>
                  </persName>
                  <idno type="halauthorid">480659-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Remy</forename>
                    <surname>Slama</surname>
                  </persName>
                  <idno type="halauthorid">1169216-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Silvia</forename>
                    <surname>Alemany</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">818637</idno>
                  <idno type="halauthorid" notation="string">2375536-818637</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7925-6767</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>Basagaña</surname>
                  </persName>
                  <email type="md5">c1fe14559c26d6e84c5e9003a0f6e1f1</email>
                  <email type="domain">isglobal.org</email>
                  <idno type="idhal" notation="numeric">767899</idno>
                  <idno type="halauthorid" notation="string">534028-767899</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8457-1489</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Plantevit</surname>
                  </persName>
                  <email type="md5">adc31f6425ef95bd13b73a6fa3cde904</email>
                  <email type="domain">liris.cnrs.fr</email>
                  <idno type="idhal" notation="string">marc-plantevit</idno>
                  <idno type="idhal" notation="numeric">2640</idno>
                  <idno type="halauthorid" notation="string">11402-2640</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4636-5753</idno>
                  <idno type="IDREF">https://www.idref.fr/125705328</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rémy</forename>
                    <surname>Cazabet</surname>
                  </persName>
                  <email type="md5">e4b9572fb4b7fb9f215b8f6561a15b85</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">remy-cazabet</idno>
                  <idno type="idhal" notation="numeric">15745</idno>
                  <idno type="halauthorid" notation="string">19315-15745</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9429-3865</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=ZPeN_HAAAAAJ&amp;hl=en&amp;oi=ao</idno>
                  <idno type="IDREF">https://www.idref.fr/176017674</idno>
                  <affiliation ref="#struct-413086"/>
                  <affiliation ref="#struct-2003"/>
                  <affiliation ref="#struct-194495"/>
                  <affiliation ref="#struct-145352"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Léa</forename>
                    <surname>Maitre</surname>
                  </persName>
                  <idno type="halauthorid">1799021-0</idno>
                  <affiliation ref="#struct-533869"/>
                  <affiliation ref="#struct-128785"/>
                  <affiliation ref="#struct-301929"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">176800</idno>
                <idno type="eissn">2730-664X</idno>
                <title level="j">Communications Medicine</title>
                <imprint>
                  <publisher>Nature</publisher>
                  <biblScope unit="volume">4</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">98</biblScope>
                  <date type="datePub">2024-05-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s43856-024-00513-y</idno>
              <idno type="pubmed">38783062</idno>
              <idno type="wos">001230220700002</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Exposome</term>
                <term xml:lang="en">Environmental Risk</term>
                <term xml:lang="en">Machine Learning</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental exposures on health are limited by the diversity of exposures included, especially for early life determinants. We used machine learning methods to build early life exposome risk scores for three health outcomes using environmental, molecular, and clinical data. Methods In this study, we analyzed data from 1622 mother-child pairs from the HELIX European birth cohorts, using over 300 environmental, 100 child peripheral, and 18 mother-child clinical markers to compute environmental-clinical risk scores (ECRS) for child behavioral difficulties, metabolic syndrome, and lung function. ECRS were computed using LASSO, Random Forest and XGBoost. XGBoost ECRS were selected to extract local feature contributions using Shapley values and derive feature importance and interactions. Results ECRS captured 13%, 50% and 4% of the variance in mental, cardiometabolic, and respiratory health, respectively. We observed no significant differences in predictive performances between the above-mentioned methods. The most important predictive features were maternal stress, noise, and lifestyle exposures for mental health; proteome (mainly IL1B) and metabolome features for cardiometabolic health; child BMI and urine metabolites for respiratory health. ConclusionsBesides their usefulness for epidemiological research, our risk scores show great potential to capture holistic individual level non-hereditary risk associations that can inform practitioners about actionable factors of high-risk children. As in the post-genetic era personalized prevention medicine will focus more and more on modifiable factors, we believe that such integrative approaches will be instrumental in shaping future healthcare paradigms.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-413086" status="VALID">
          <orgName>Data Mining and Machine Learning</orgName>
          <orgName type="acronym">DM2L</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-2003" type="direct"/>
            <relation active="#struct-33804" type="indirect"/>
            <relation active="#struct-126765" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-219748" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation name="UMR5205" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-533869" status="VALID">
          <orgName>Instituto de Salud Global - Institute For Global Health [Barcelona]</orgName>
          <orgName type="acronym">ISGlobal</orgName>
          <desc>
            <address>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.isglobal.org/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1002409" status="VALID">
          <idno type="IdRef">196443806</idno>
          <idno type="RNSR">201420738K</idno>
          <orgName>Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques</orgName>
          <orgName type="acronym">CRESS (U1153 / UMR_A 1125)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Hôtel-Dieu - 1 place du Parvis Notre-Dame - 75004 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://cress-umr1153.fr/en/#thecentre</ref>
          </desc>
          <listRelation>
            <relation name="U1153" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 1153" active="#struct-557826" type="direct"/>
            <relation name="UMR1125" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2003" status="VALID">
          <idno type="IdRef">149705271</idno>
          <idno type="ISNI">0000000122577669</idno>
          <idno type="RNSR">200511875R</idno>
          <idno type="ROR">https://ror.org/04dv4he91</idno>
          <orgName>Laboratoire d'InfoRmatique en Image et Systèmes d'information</orgName>
          <orgName type="acronym">LIRIS</orgName>
          <date type="start">2003-01-01</date>
          <desc>
            <address>
              <addrLine>Bâtiment Blaise Pascal - 20, avenue Albert Einstein - 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://liris.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-33804" type="direct"/>
            <relation active="#struct-126765" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation name="UMR5205" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-145352" status="VALID">
          <idno type="IdRef">236299182</idno>
          <orgName>Institut Rhône-Alpin des systèmes complexes</orgName>
          <orgName type="acronym">IXXI</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46, allée d'Italie 69007 LYON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ixxi.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-6818" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-33804" type="direct"/>
            <relation active="#struct-118744" type="direct"/>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300009" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-128785" status="VALID">
          <idno type="ROR">https://ror.org/04n0g0b29</idno>
          <orgName>Universitat Pompeu Fabra [Barcelona]</orgName>
          <orgName type="acronym">UPF</orgName>
          <desc>
            <address>
              <addrLine>Plaça de la Mercè, 10-12 - 08002 Barcelona</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.upf.edu/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301929" status="VALID">
          <idno type="ROR">https://ror.org/050q0kv47</idno>
          <orgName>Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública =  Consortium for Biomedical Research of Epidemiology and Public Health</orgName>
          <orgName type="acronym">CIBERESP</orgName>
          <desc>
            <address>
              <addrLine>Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0 28029, Madrid</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.ciberesp.es</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-33804" status="VALID">
          <idno type="IdRef">02640334X</idno>
          <idno type="ISNI">0000 0001 2188 0906</idno>
          <idno type="ROR">https://ror.org/03rth4p18</idno>
          <idno type="Wikidata">Q4041</idno>
          <orgName>Université Lumière - Lyon 2</orgName>
          <orgName type="acronym">UL2</orgName>
          <desc>
            <address>
              <addrLine>86, rue Pasteur - 69007 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon2.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-126765" status="VALID">
          <idno type="ROR">https://ror.org/05s6rge65</idno>
          <orgName>École Centrale de Lyon</orgName>
          <orgName type="acronym">ECL</orgName>
          <desc>
            <address>
              <addrLine>36 avenue Guy de Collongue - 69134 Ecully cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ec-lyon.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-219748" status="VALID">
          <idno type="IdRef">052444724</idno>
          <idno type="ISNI">0000 0001 2292 0228</idno>
          <orgName>Institut National des Sciences Appliquées de Lyon</orgName>
          <orgName type="acronym">INSA Lyon</orgName>
          <date type="start">1957-03-18</date>
          <desc>
            <address>
              <addrLine>20 Avenue Albert Einstein, 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-6818" status="VALID">
          <idno type="IdRef">149154992</idno>
          <idno type="ISNI">0000000123319856</idno>
          <idno type="ROR">https://ror.org/04zmssz18</idno>
          <idno type="Wikidata">Q10159</idno>
          <orgName>École normale supérieure de Lyon</orgName>
          <orgName type="acronym">ENS de Lyon</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ens-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-118744" status="VALID">
          <idno type="IdRef">026404494</idno>
          <idno type="ISNI">0000000121920883</idno>
          <idno type="ROR">https://ror.org/05b5c0584</idno>
          <orgName>Université Jean Moulin - Lyon 3</orgName>
          <orgName type="acronym">UJML</orgName>
          <date type="start">1973-07-26</date>
          <desc>
            <address>
              <addrLine>6 cours Albert Thomas - 69008 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon3.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>