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Article Dans Une Revue Biomedicine and Pharmacotherapy Année : 2024

Ganglioside GM3-based anticancer vaccines: Reviewing the mechanism and current strategies

Résumé

Ganglioside GM3 is one of the most common membrane-bound glycosphingolipids. The over-expression of GM3 on tumor cells makes it defined as a tumor-associated carbohydrate antigen (TACA). The specific expression property in cancers, especially in melanoma, make it become an important target to develop anticancer vaccines or immunotherapies. However, in the manner akin to most TACAs, GM3 is an autoantigen facing with problems of low immunogenicity and easily inducing immunotolerance, which means itself only cannot elicit a powerful enough immune response to prevent or treat cancer. With a comparative understanding of the mechanisms that how immune system responses to the carbohydrate vaccines, this review summarizes the studies on the recent efforts to development GM3-based anticancer vaccines.

Mots clés

cytidine mono-phospho- dendritic cell ELISA enzyme-linked immunosorbent assay tumor-associated carbohydrate antigen GSL glycosphingolipid HSA human serum albumin iNKT invariant natural killer T KLH keyhole limpet hemocyanin LacCer lactosylceramide LPS lipopolysaccharide mAb monoclonal antibody MHC major histocompatibility complex MPLA mono-phosphoryl lipid A OVA ovalbumin PAMP pathogen-associated molecular pattern PRR pattern recognition receptor TCR T cell receptor TME tumor microenvironment TTox tetanus toxoid TLRs toll-like receptors VSSP very small size proteoliposomes VLP virus-like particle Glc glucose Man mannose Gal galactose GlcNAc GM3 TACA Anticancer Vaccine Glycoconjugate Glycoimmunology APC antigen-presenting cell BCR B cell receptor BSA bovine serum albumin CDC complement dependent cytotoxicity CMAH cytidine mono-phospho- dendritic cell ELISA enzyme-linked immunosorbent assay TACA tumor-associated carbohydrate antigen GSL glycosphingolipid HSA human serum albumin iNKT invariant natural killer T KLH keyhole limpet hemocyanin LacCer lactosylceramide LPS lipopolysaccharide mAb monoclonal antibody MHC major histocompatibility complex MPLA mono-phosphoryl lipid A OVA ovalbumin PAMP pathogen-associated molecular pattern PRR pattern recognition receptor TCR T cell receptor TME tumor microenvironment TTox tetanus toxoid TLRs toll-like receptors VSSP very small size proteoliposomes VLP virus-like particle Glc glucose Man mannose Gal galactose GlcNAc antigen-presenting cell BCR B cell receptor BSA bovine serum albumin CDC complement dependent cytotoxicity CMAH

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Dates et versions

hal-04601444 , version 1 (05-06-2024)

Identifiants

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Jiaxu Zhang, Marco Terreni, Fang Liu, Matthieu Sollogoub, Yongmin Zhang. Ganglioside GM3-based anticancer vaccines: Reviewing the mechanism and current strategies. Biomedicine and Pharmacotherapy, 2024, 176, pp.116824. ⟨10.1016/j.biopha.2024.116824⟩. ⟨hal-04601444⟩
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