Ganglioside GM3-based anticancer vaccines: Reviewing the mechanism and current strategies
Résumé
Ganglioside GM3 is one of the most common membrane-bound glycosphingolipids. The over-expression of GM3 on tumor cells makes it defined as a tumor-associated carbohydrate antigen (TACA). The specific expression property in cancers, especially in melanoma, make it become an important target to develop anticancer vaccines or immunotherapies. However, in the manner akin to most TACAs, GM3 is an autoantigen facing with problems of low immunogenicity and easily inducing immunotolerance, which means itself only cannot elicit a powerful enough immune response to prevent or treat cancer. With a comparative understanding of the mechanisms that how immune system responses to the carbohydrate vaccines, this review summarizes the studies on the recent efforts to development GM3-based anticancer vaccines.
Mots clés
cytidine mono-phospho- dendritic cell
ELISA
enzyme-linked immunosorbent assay
tumor-associated carbohydrate antigen
GSL
glycosphingolipid
HSA
human serum albumin
iNKT
invariant natural killer T
KLH
keyhole limpet hemocyanin
LacCer
lactosylceramide
LPS
lipopolysaccharide
mAb
monoclonal antibody
MHC
major histocompatibility complex
MPLA
mono-phosphoryl lipid A
OVA
ovalbumin
PAMP
pathogen-associated molecular pattern
PRR
pattern recognition receptor
TCR
T cell receptor
TME
tumor microenvironment
TTox
tetanus toxoid
TLRs
toll-like receptors
VSSP
very small size proteoliposomes
VLP
virus-like particle
Glc
glucose
Man
mannose
Gal
galactose
GlcNAc
GM3
TACA
Anticancer Vaccine
Glycoconjugate
Glycoimmunology APC
antigen-presenting cell BCR
B cell receptor BSA
bovine serum albumin CDC
complement dependent cytotoxicity CMAH
cytidine mono-phospho- dendritic cell ELISA
enzyme-linked immunosorbent assay TACA
tumor-associated carbohydrate antigen GSL
glycosphingolipid HSA
human serum albumin iNKT
invariant natural killer T KLH
keyhole limpet hemocyanin LacCer
lactosylceramide LPS
lipopolysaccharide mAb
monoclonal antibody MHC
major histocompatibility complex MPLA
mono-phosphoryl lipid A OVA
ovalbumin PAMP
pathogen-associated molecular pattern PRR
pattern recognition receptor TCR
T cell receptor TME
tumor microenvironment TTox
tetanus toxoid TLRs
toll-like receptors VSSP
very small size proteoliposomes VLP
virus-like particle Glc
glucose Man
mannose Gal
galactose GlcNAc
antigen-presenting cell
BCR
B cell receptor
BSA
bovine serum albumin
CDC
complement dependent cytotoxicity
CMAH
Domaines
Chimie
Fichier principal
Revised Manuscript.pdf (2.24 Mo)
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Revised Manuscript (1).pdf (2.24 Mo)
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