Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents
Résumé
α-anomeric uridylates, α-rU6 and α-rU12, have been synthesized for the first time. These non natural α-oligoribonucleotides strongly resist to enzymatic degradation and bind to complementary RNA strands.
Domaines
Chimie
Fichier principal
Tetrahedron Letters 1990 Vol. 31 Pages 3537-3540_test.pdf (227.84 Ko)
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