Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents - Archive ouverte HAL
Article Dans Une Revue Tetrahedron Letters Année : 1990

Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

Résumé

α-anomeric uridylates, α-rU6 and α-rU12, have been synthesized for the first time. These non natural α-oligoribonucleotides strongly resist to enzymatic degradation and bind to complementary RNA strands.

Domaines

Chimie
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Dates et versions

hal-04600829 , version 1 (04-06-2024)

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Francoise Debart, Bernard Rayner, Jeon-Louis Imbach. Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents. Tetrahedron Letters, 1990, 31 (25), pp.3537-3540. ⟨10.1016/S0040-4039(00)94436-8⟩. ⟨hal-04600829⟩
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