Inference for the stochastic FitzHugh-Nagumo model from real action potential data via approximate Bayesian computation - Archive ouverte HAL
Article Dans Une Revue Computational Statistics and Data Analysis Année : 2024

Inference for the stochastic FitzHugh-Nagumo model from real action potential data via approximate Bayesian computation

Adeline Samson
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Massimiliano Tamborrino
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Irene Tubikanec
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  • PersonId : 1195027

Résumé

The stochastic FitzHugh-Nagumo (FHN) model considered here is a two-dimensional nonlinear stochastic differential equation with additive degenerate noise, whose first component, the only one observed, describes the membrane voltage evolution of a single neuron. Due to its low dimensionality, its analytical and numerical tractability, and its neuronal interpretation, it has been used as a case study to test the performance of different statistical methods in estimating the underlying model parameters. Existing methods, however, often require complete observations, non-degeneracy of the noise or a complex architecture (e.g., to estimate the transition density of the process, "recovering" the unobserved second component), and they may not (satisfactorily) estimate all model parameters simultaneously. Moreover, these studies lack real data applications for the stochastic FHN model. Here, we tackle all challenges (non-globally Lipschitz drift, non-explicit solution, lack of available transition density, degeneracy of the noise, and partial observations) via an intuitive and easy-to-implement sequential Monte Carlo approximate Bayesian computation algorithm. The proposed method relies on a recent computationally efficient and structure-preserving numerical splitting scheme for synthetic data generation, and on summary statistics exploiting the structural properties of the process. We succeed in estimating all model parameters from simulated data and, more remarkably, real action potential data of rats. The presented novel real-data fit may broaden the scope and credibility of this classic and widely used neuronal model.
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Dates et versions

hal-04600178 , version 1 (04-06-2024)

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Adeline Samson, Massimiliano Tamborrino, Irene Tubikanec. Inference for the stochastic FitzHugh-Nagumo model from real action potential data via approximate Bayesian computation. Computational Statistics and Data Analysis, In press. ⟨hal-04600178⟩

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