Inference for the stochastic FitzHugh-Nagumo model from real action potential data via approximate Bayesian computation
Résumé
The stochastic FitzHugh-Nagumo (FHN) model considered here is a two-dimensional nonlinear stochastic differential equation with additive degenerate noise, whose first component, the only one observed, describes the membrane voltage evolution of a single neuron. Due to its low dimensionality, its analytical and numerical tractability, and its neuronal interpretation, it has been used as a case study to test the performance of different statistical methods in estimating the underlying model parameters. Existing methods, however, often require complete observations, non-degeneracy of the noise or a complex architecture (e.g., to estimate the transition density of the process, "recovering" the unobserved second component), and they may not (satisfactorily) estimate all model parameters simultaneously. Moreover, these studies lack real data applications for the stochastic FHN model. Here, we tackle all challenges (non-globally Lipschitz drift, non-explicit solution, lack of available transition density, degeneracy of the noise, and partial observations) via an intuitive and easy-to-implement sequential Monte Carlo approximate Bayesian computation algorithm. The proposed method relies on a recent computationally efficient and structure-preserving numerical splitting scheme for synthetic data generation, and on summary statistics exploiting the structural properties of the process. We succeed in estimating all model parameters from simulated data and, more remarkably, real action potential data of rats. The presented novel real-data fit may broaden the scope and credibility of this classic and widely used neuronal model.
Mots clés
FitzHugh-Nagumo model Action potential data Hypoellipticity Splitting numerical methods Bayesian inference Sequential Monte Carlo approximate Bayesian computation AMS subject classifications 60H10 60H35 65C30
FitzHugh-Nagumo model
Action potential data
Hypoellipticity
Splitting numerical methods
Bayesian inference
Sequential Monte Carlo approximate Bayesian computation AMS subject classifications 60H10
60H35
65C30
Domaines
Mathématiques [math]Origine | Fichiers produits par l'(les) auteur(s) |
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