Article Dans Une Revue Neuromuscular Disorders Année : 2024

The 2024 version of the gene table of neuromuscular disorders (nuclear genome)

Résumé

Abstract Aim To study long‐term sequelae in children with Guillain–Barré syndrome (GBS). Method This was a prospective observational study with children from two French tertiary centres. Data were from clinical and several standardized scales or questionnaires. Results Fifty‐one patients were included with a median follow‐up of 6 years 4 months (range 3–20 years) after the acute phase. The sequelae rate was 67% (95% confidence interval [CI] 53–78) and did not vary with time. Most children had minor sequelae (Guillain–Barré Syndrome Disability Score [GBSDS] = 1); only one was unable to run (GBSDS = 2). The most frequent complaints were paraesthesia (43%), pain (35%), and fatigue (31%). The neurological examination was abnormal in 18% of children, autonomy was compromised in 14%, and symptoms of depression occurred in 34%. The factors associated with late‐onset sequelae were correlated with severity during the initial phase (i.e. initial GBSDS >4, odds ratio 6.6, 95% CI 1.8–33; p = 0.009). The predictive factors of more severe late‐onset conditions were initial severity ( p = 0.002) and sex (female patients; p = 0.01). Interpretation Two‐thirds of children with GBS had late‐onset sequelae following an episode, often minor, but sometimes with continuing effects on their everyday lives. Particularly affected were those who had severe GBS during the acute phase and who lost the ability to walk. What this paper adds Two‐thirds of children with Guillain–Barré syndrome (GBS) had persistent sequelae. Sequelae were often minor, but daily repercussions of them were sometimes serious. Sequelae were significantly associated with severe GBS during the acute phase.

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hal-04597257 , version 1 (20-01-2025)

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Louise Benarroch, Gisèle Bonne, Francois Rivier, Dalil Hamroun. The 2024 version of the gene table of neuromuscular disorders (nuclear genome). Neuromuscular Disorders, 2024, 34 (2), pp.126-170. ⟨10.1016/j.nmd.2023.12.007⟩. ⟨hal-04597257⟩
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