The rapid advancement of artificial intelligence (AI) has brought significant challenges to the education and workforce skills required to take advantage of AI for human-AI collaboration in the workplace. As AI continues to reshape industries and job markets, the need to define how AI literacy can be considered in lifelong learning has become increasingly critical (Cetindamar et al., 2022; Laupichler et al., 2022; Romero et al., 2023). Like any new technology, AI is the subject of both hopes and fears, and what it entails today presents major challenges (Cugurullo & Acheampong, 2023; Villani et al., 2018). It also raises profound questions about our own humanity. Will the machine surpass the intelligence of the humans who designed it? What will be the relationship between so-called AI and our human intelligences? How could human-AI collaboration be regulated in a way that serves the Sustainable Development Goals (SDGs)? This paper provides a review of the challenges of lifelong learning in the era of AI from a computational thinking, critical thinking, and creative competencies perspective, highlighting the implications for management and leadership in organizations.