Expanding the ‘aplysinospin cascade’ through DNA-templated [2+2] photocycloaddition
Résumé
Inspired by the unique ability of nucleic acids to template chemical transformations that are otherwise impossible in solution, we embarked on the generalisation of our DNA-templated [2+2] photo-induced homo- and heterodimerization of aplysinopsins. Our process ensures a straightforward access to cyclobutane containing natural products and analogues thereof. Most importantly, this conceptual biomimetic achievement presents interesting arguments to build a biosynthetic scenario.
Domaines
Chimie thérapeutique| Origine | Publication financée par une institution |
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