<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04591904</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T06:56:13+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Insular functional connectivity in migraine with aura</title>
            <author role="aut">
              <persName>
                <forename type="first">Cédric</forename>
                <surname>Gollion</surname>
              </persName>
              <idno type="halauthorid">2442530-0</idno>
              <affiliation ref="#struct-521838"/>
              <affiliation ref="#struct-547851"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fleur</forename>
                <surname>Lerebours</surname>
              </persName>
              <idno type="halauthorid">2428758-0</idno>
              <affiliation ref="#struct-547851"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Federico</forename>
                <surname>Nemmi</surname>
              </persName>
              <idno type="halauthorid">736396-0</idno>
              <affiliation ref="#struct-521838"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Germain</forename>
                <surname>Arribarat</surname>
              </persName>
              <idno type="halauthorid">1795393-0</idno>
              <affiliation ref="#struct-521838"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabrice</forename>
                <surname>Bonneville</surname>
              </persName>
              <idno type="halauthorid">309449-0</idno>
              <affiliation ref="#struct-521838"/>
              <affiliation ref="#struct-183002"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Larrue</surname>
              </persName>
              <idno type="halauthorid">409221-0</idno>
              <affiliation ref="#struct-547851"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrice</forename>
                <surname>Péran</surname>
              </persName>
              <email type="md5">21c52dec9aabe97a74b657893bc9b9eb</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">patrice-peran</idno>
              <idno type="idhal" notation="numeric">1225011</idno>
              <idno type="halauthorid" notation="string">619522-1225011</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7200-0139</idno>
              <idno type="IDREF">https://www.idref.fr/083952098</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=DIpRzDQAAAAJ</idno>
              <affiliation ref="#struct-521838"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Karine</forename>
                <surname>Pistre</surname>
              </persName>
              <email type="md5">f1652ba390450bfba6359c7733d50f17</email>
              <email type="domain">univ-tlse3.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-10-15 11:24:36</date>
              <date type="whenModified">2025-10-22 18:04:09</date>
              <date type="whenReleased">2024-10-15 13:28:07</date>
              <date type="whenProduced">2022-08-19</date>
              <date type="whenEndEmbargoed">2024-10-15</date>
              <ref type="file" target="https://hal.science/hal-04591904v1/document">
                <date notBefore="2024-10-15"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04591904v1/file/Gollion_2022.pdf" id="file-4737224-4124409">
                <date notBefore="2024-10-15"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389744"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="996101">
                <persName>
                  <forename>Karine</forename>
                  <surname>Pistre</surname>
                </persName>
                <email type="md5">f1652ba390450bfba6359c7733d50f17</email>
                <email type="domain">univ-tlse3.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04591904</idno>
            <idno type="halUri">https://hal.science/hal-04591904</idno>
            <idno type="halBibtex">gollion:hal-04591904</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Headache and Pain&lt;/i&gt;, 2022, 23 (1), pp.106. &lt;a target="_blank" href="https://dx.doi.org/10.1186/s10194-022-01473-1"&gt;&amp;#x27E8;10.1186/s10194-022-01473-1&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Headache and Pain, 2022, 23 (1), pp.106. &amp;#x27E8;10.1186/s10194-022-01473-1&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-4737224-4124409"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-TLSE2">Université Toulouse 2</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="TONIC">TONIC</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Insular functional connectivity in migraine with aura</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Cédric</forename>
                    <surname>Gollion</surname>
                  </persName>
                  <idno type="halauthorid">2442530-0</idno>
                  <affiliation ref="#struct-521838"/>
                  <affiliation ref="#struct-547851"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fleur</forename>
                    <surname>Lerebours</surname>
                  </persName>
                  <idno type="halauthorid">2428758-0</idno>
                  <affiliation ref="#struct-547851"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Federico</forename>
                    <surname>Nemmi</surname>
                  </persName>
                  <idno type="halauthorid">736396-0</idno>
                  <affiliation ref="#struct-521838"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Germain</forename>
                    <surname>Arribarat</surname>
                  </persName>
                  <idno type="halauthorid">1795393-0</idno>
                  <affiliation ref="#struct-521838"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrice</forename>
                    <surname>Bonneville</surname>
                  </persName>
                  <idno type="halauthorid">309449-0</idno>
                  <affiliation ref="#struct-521838"/>
                  <affiliation ref="#struct-183002"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Larrue</surname>
                  </persName>
                  <idno type="halauthorid">409221-0</idno>
                  <affiliation ref="#struct-547851"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrice</forename>
                    <surname>Péran</surname>
                  </persName>
                  <email type="md5">21c52dec9aabe97a74b657893bc9b9eb</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">patrice-peran</idno>
                  <idno type="idhal" notation="numeric">1225011</idno>
                  <idno type="halauthorid" notation="string">619522-1225011</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7200-0139</idno>
                  <idno type="IDREF">https://www.idref.fr/083952098</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=DIpRzDQAAAAJ</idno>
                  <affiliation ref="#struct-521838"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13991</idno>
                <idno type="issn">1129-2369</idno>
                <idno type="eissn">1129-2377</idno>
                <title level="j">Journal of Headache and Pain</title>
                <imprint>
                  <publisher>SpringerOpen</publisher>
                  <biblScope unit="volume">23</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">106</biblScope>
                  <date type="datePub">2022-08-19</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/s10194-022-01473-1</idno>
              <idno type="pubmed">35982396</idno>
              <idno type="pubmedcentral">PMC9389744</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Cerebellum vermis</term>
                <term xml:lang="en">Functional MRI</term>
                <term xml:lang="en">Insula</term>
                <term xml:lang="en">MRI</term>
                <term xml:lang="en">Migraine</term>
                <term xml:lang="en">Migraine with aura</term>
              </keywords>
              <classCode scheme="mesh">Cerebellum</classCode>
              <classCode scheme="mesh">Epilepsy</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Magnetic Resonance Imaging</classCode>
              <classCode scheme="mesh">Migraine Disorders</classCode>
              <classCode scheme="mesh">Migraine with Aura</classCode>
              <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Introduction: Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functions. This study aimed at investigating functional connectivity of insula subregions in MA.Methods: Twenty-one interictal patients with MA were compared to 18 healthy controls (HC) and 12 interictal patients with migraine without aura (MO) and were scanned with functional MRI during the resting state. Functional coupling of the insula was comprehensively tested with 12 seeds located in the right and left, dorsal, middle, ventral, anterior and posterior insula, by using a seed-to-voxel analysis.Results: Seed-to-voxel analysis revealed, in MA, a strong functional coupling of the right and left antero-dorsal insula with clusters located in the upper cerebellum. The overlap of these cerebellar clusters corresponded to the vermis VI. These functional couplings were not correlated to duration of MA, frequency of MA attacks nor time since last MA attack, and were not found in MO.Discussion: The anterior insula and superior cerebellum, including vermis VI, are components of the central Autonomic Nervous System (ANS) network. As these regions are involved in the control of cardiovascular parasympathetic tone, we hypothesize that this connectivity may reflect the cardiovascular features of MA.Conclusion: The anterior dorsal insula is connected with vermis VI in MA patients in the resting state. This connectivity may reflect the cardiovascular features of MA.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-521838" status="OLD">
          <idno type="IdRef">238303470</idno>
          <idno type="RNSR">200716480M</idno>
          <orgName>Toulouse NeuroImaging Center</orgName>
          <orgName type="acronym">ToNIC</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>CHU PURPAN - Pavillon Baudot - Place du Dr Baylac 31024 TOULOUSE - Cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://tonic.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR825" active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="U1214" active="#struct-303623" type="direct"/>
            <relation active="#struct-1149079" type="direct"/>
            <relation active="#struct-116256" type="indirect"/>
            <relation name="FED4171" active="#struct-217752" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-547851" status="VALID">
          <orgName>Département Neurologie [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Pierre-Paul Riquet, Place du Docteur Baylac - TSA 40031 - 31059 Toulouse cedex 9, 3e étage - hall B</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr/-neurologie-departement-</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455510" type="direct"/>
            <relation active="#struct-300075" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-183002" status="VALID">
          <orgName>Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Pierre-Paul Riquet, Place du Docteur Baylac - TSA 40031 - 31059 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-toulouse.fr/-neuroradiologie-diagnostique-therapeutique,162-</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1153203" type="direct"/>
            <relation active="#struct-300075" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1149079" status="OLD">
          <orgName>Toulouse Mind &amp; Brain Institut</orgName>
          <orgName type="acronym">TMBI</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>CHU Purpan, Pavillon Baudot, 31059 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.tmbi.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-116256" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="FED4171" active="#struct-217752" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-116256" status="VALID">
          <idno type="IdRef">026403994</idno>
          <idno type="ROR">https://ror.org/04ezk3x31</idno>
          <orgName>Université Toulouse - Jean Jaurès</orgName>
          <orgName type="acronym">UT2J</orgName>
          <date type="start">1971-01-01</date>
          <desc>
            <address>
              <addrLine>5 allées Antonio Machado - 31058 Toulouse Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse2.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-455510" status="VALID">
          <orgName>Pôle Neurosciences [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>place du Dr-Baylac, 31059 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-toulouse.fr/-pole-neurosciences-</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300075" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1153203" status="VALID">
          <orgName>Pôle imagerie médicale [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>Toulouse</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300075" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>