Article Dans Une Revue Acta Neuropsychiatrica Année : 2016

Structural–functional brain changes in depressed patients during and after electroconvulsive therapy

Antoine Yrondi
  • Fonction : Auteur
Patrice Péran
Anne Sauvaget
  • Fonction : Auteur
Laurent Schmitt
  • Fonction : Auteur
Christophe Arbus
  • Fonction : Auteur

Résumé

Objectives Electroconvulsive therapy (ECT) is a non-pharmacological treatment that is effective in treating severe and treatment-resistant depression. Although the efficacy of ECT has been demonstrated to treat major depressive disorder (MDD), the brain mechanisms underlying this process remain unclear. Structural–functional changes occur with the use of ECT as a treatment for depression based on magnetic resonance imaging (MRI). For this reason, we have tried to identify the changes that were identified by MRI to try to clarify some operating mechanisms of ECT. We focus to brain changes on MRI [structural MRI (sMRI), functional MRI (fMRI) and diffusion tensor imging (DTI)] after ECT. Methods A systematic search of the international literature was performed using the bibliographic search engines PubMed and Embase. The research focused on papers published up to 30 September 2015. The following Medical Subject Headings (MESH) terms were used: electroconvulsive therapy AND (MRI OR fMRI OR DTI). Papers published in English were included. Four authors searched the database using a predefined strategy to identify potentially eligible studies. Results There were structural changes according to the sMRI performed before and after ECT treatment. These changes do not seem to be entirely due to oedema. This investigation assessed the functional network connectivity associated with the ECT response in MDD. ECT response reverses the relationship from negative to positive between the two pairs of networks. Conclusion We found structural–functional changes in MRI post-ECT. Because of the currently limited MRI data on ECT in the literature, it is necessary to conduct further investigations using other MRI technology.

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Dates et versions

hal-04591417 , version 1 (28-05-2024)

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Antoine Yrondi, Patrice Péran, Anne Sauvaget, Laurent Schmitt, Christophe Arbus. Structural–functional brain changes in depressed patients during and after electroconvulsive therapy. Acta Neuropsychiatrica, 2016, 30 (1), pp.17-28. ⟨10.1017/neu.2016.62⟩. ⟨hal-04591417⟩
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