Article Dans Une Revue Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Année : 2024

Brain tissues atrophy is not always the best structural biomarker of physiological aging: A multimodal cross-sectional study

Andrea Cherubini
  • Fonction : Auteur
Maria Eugenia Caligiuri
  • Fonction : Auteur
Umberto Sabatini
  • Fonction : Auteur
Carlo Cosentino
  • Fonction : Auteur
Francesco Amato
  • Fonction : Auteur

Résumé

This study presents a voxel-based multiple regression analysis of different magnetic resonance image modalities, including anatomical T1-weighted, T2* relaxometry, and diffusion tensor imaging. Quantitative parameters sensitive to complementary brain tissue alterations, including morphometric atrophy, mineralization, microstructural damage, and anisotropy loss, were compared in a linear physiological aging model in 140 healthy subjects (range 20-74 years). The performance of different predictors and the identification of the best biomarker of age-induced structural variation were compared without a priori anatomical knowledge. The best quantitative predictors in several brain regions were iron deposition and microstructural damage, rather than macroscopic tissue atrophy. Age variations were best resolved with a combination of markers, suggesting that multiple predictors better capture age-induced tissue alterations. These findings highlight the importance of a combined evaluation of multimodal biomarkers for the study of aging and point to a number of novel applications for the method described.

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Dates et versions

hal-04591393 , version 1 (28-05-2024)

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Andrea Cherubini, Maria Eugenia Caligiuri, Patrice Peran, Umberto Sabatini, Carlo Cosentino, et al.. Brain tissues atrophy is not always the best structural biomarker of physiological aging: A multimodal cross-sectional study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2024, 2015, pp.5436-5440. ⟨10.1109/EMBC.2015.7319621⟩. ⟨hal-04591393⟩
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