Article Dans Une Revue Chemistry - A European Journal Année : 2024

Metal‐free decarboxylative allylation of oxime esters under light irradiation

Résumé

Allylation reactions, often used as a key step forconstructing complex molecules and drug candidates, typically rely ontransition-metal (TM) catalysts. Even though TM-free radicalallylations have been developed using allyl-stannanes, -sulfides, -silanes or -sulfones, much less procedures have been reported usingsimple and commercially available allyl halides, that are used for thepreparation of the before-mentioned allyl derivatives. Here, wepresent a straightforward photocatalytic protocol for thedecarboxylative allylation of oxime esters using allyl bromidederivatives under metal-free and mild conditions. This methodologyyields a diverse variety of functionalized molecules including severalpharmaceutically relevant molecules.

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Chimie organique
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Chemistry A European J - 2024 - Geniller - Metal‐Free Decarboxylative Allylation of Oxime Esters under Light Irradiation.pdf (3) Télécharger le fichier
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Dates et versions

hal-04587922 , version 1 (10-07-2024)

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Lilian Geniller, Hiba Ben Kraim, Eric Clot, Marc Taillefer, Florian Jaroschik, et al.. Metal‐free decarboxylative allylation of oxime esters under light irradiation. Chemistry - A European Journal, In press, ⟨10.1002/chem.202401494⟩. ⟨hal-04587922⟩
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