Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis - Archive ouverte HAL
Article Dans Une Revue Science Année : 2024

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis

Liang Chi
National Institute of Allergy and Infectious Diseases [Bethesda]
Can Liu
Human-Computer Interaction Laboratory
City University of Hong Kong [Hong Kong]
Inta Gribonika
Julia Gschwend
Dan Corral
Institut de pharmacologie et de biologie structurale
National Institute of Allergy and Infectious Diseases [Bethesda]
Seong-Ji Han
  • Fonction : Auteur
Ai Ing Lim
National Institute of Allergy and Infectious Diseases [Bethesda]
Claudia Rivera
  • Fonction : Auteur
Instituto de Ciencias de la Atmósfera y Cambio Climático
Verena Link
Alexandria Wells
Nicolas Bouladoux
Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires
Nicholas Collins
  • Fonction : Auteur
Exploration of the Universe Division, Observational Cosmology Laboratory
Djalma Lima-Junior
Michel Enamorado
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Barbara Rehermann
National Institute of Diabetes and Digestive and Kidney Diseases [Bethesda]
Sophie Laffont
Institut Toulousain des Maladies Infectieuses et Inflammatoires
Jean-Charles Guéry
Institut Toulousain des Maladies Infectieuses et Inflammatoires
CV
Roxane Tussiwand
Université de Bâle = University of Basel = Basel Universität
Christoph Schneider
Westfälische Wilhelms-Universität Münster = University of Münster
Yasmine Belkaid
National Institute of Allergy and Infectious Diseases [Bethesda]

Résumé

Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reduction in dendritic cell accumulation and activation in males, along with reduced tissue immunity. Collectively, our results reveal a role for the androgen-ILC2-dendritic cell axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.

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Sciences du Vivant [q-bio]

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https://hal.science/hal-04585729

Soumis le : jeudi 23 mai 2024-17:42:14

Dernière modification le : jeudi 28 novembre 2024-14:42:02

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Liang Chi, Can Liu, Inta Gribonika, Julia Gschwend, Dan Corral, et al.. Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis. Science, 2024, 384 (6692), ⟨10.1126/science.adk6200⟩. ⟨hal-04585729⟩

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