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                <term xml:lang="fr">Atrial fibrillation</term>
                <term xml:lang="fr">Edoxaban</term>
                <term xml:lang="fr">Non-vitamin K oral anticoagulant</term>
                <term xml:lang="fr">Real-world</term>
                <term xml:lang="fr">Registry</term>
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              <p>Aims: Patients with atrial fibrillation (AF) treated with oral anticoagulation still suffer from cardiovascular complications including cardiovascular death, stroke, and major bleeding. To identify risk factors for predicting stroke and bleeding outcomes in anticoagulated patients, we assessed 2-year outcomes in patients with AF treated with edoxaban in routine care. We also report the age-adjusted risk predictors of clinical outcomes.Methods and results: The Edoxaban Treatment in Routine Clinical Practice for Patients With Non-Valvular Atrial Fibrillation (ETNA-AF) Europe (NCT02944019) is a prospective, multi-centre, post-authorisation, observational study with an overall 4-year follow-up conducted in 825 centres enrolling edoxaban-treated patients in 10 European countries. Of the 13 133 patients with AF (mean age: 73.6 ± 9.5 years), 5682 (43.3%) were female. At the 2-year follow-up, 9017/13 133 patients were still on edoxaban; 1830 discontinued treatment including 937 who died (annualised event rate of all-cause death was 3.87%). 518 (2.14%) patients died of cardiovascular causes; 234 (0.97%) experienced major bleeding and 168 (0.70%) experienced stroke or systemic embolic events (SEE). Intracranial haemorrhage was noted in 49 patients (0.20%). History of transient ischaemic attack (TIA) at baseline was the strongest predictor of ischaemic stroke or SEE (Wald χ2: 73.63; P &lt; 0.0001). Low kidney function at baseline was the strongest predictor of major bleeding (Wald χ2: 30.68; P &lt; 0.0001). History of heart failure (HF) was the strongest predictor of all-cause (Wald χ2: 146.99; P &lt; 0.0001) and cardiovascular death (Wald χ2: 100.38; P &lt; 0.0001).Conclusion: Patients treated with edoxaban in ETNA-AF-Europe reported low 2-year event rates in unselected AF patients. Prior stroke, reduced kidney function, and HF identify patients at high risk of stroke, bleeding and all-cause/cardiovascular death, respectively.</p>
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          <orgName>Munich Cluster for systems neurology [Munich]</orgName>
          <orgName type="acronym">SyNergy</orgName>
          <desc>
            <address>
              <addrLine>Feodor-Lynen-Str. 1781377 Munich</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.synergy-munich.de</ref>
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        <org type="institution" xml:id="struct-531291" status="VALID">
          <idno type="ROR">https://ror.org/027y26122</idno>
          <orgName>Daiichi Sankyo Co.</orgName>
          <desc>
            <address>
              <addrLine>3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo103-8426 Japan</addrLine>
              <country key="JP"/>
            </address>
            <ref type="url">https://www.daiichisankyo.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-30151" status="VALID">
          <orgName>Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf  [Hamburg]</orgName>
          <orgName type="acronym">UKE</orgName>
          <date type="start">1889</date>
          <desc>
            <address>
              <addrLine>Martinistraße 5220251 Hamburg</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uke.de/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-455354" status="VALID">
          <orgName>Berlin Institute of Health</orgName>
          <orgName type="acronym">BIH</orgName>
          <desc>
            <address>
              <country key="DE"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1085123" status="VALID">
          <orgName>Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière]</orgName>
          <orgName type="acronym">IHU ICAN</orgName>
          <desc>
            <address>
              <addrLine>Hôpital la Pitié Salpêtrière47-83 boulevard de l’Hôpital75013 Paris 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ihuican.org/</ref>
          </desc>
          <listRelation>
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        </org>
        <org type="institution" xml:id="struct-353778" status="VALID">
          <idno type="ROR">https://ror.org/02mh9a093</idno>
          <orgName>CHU Pitié-Salpêtrière [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
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          <listRelation>
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        <org type="regroupinstitution" xml:id="struct-120654" status="VALID">
          <idno type="IdRef">026431610</idno>
          <idno type="ISNI">0000 0000 8499 2262</idno>
          <idno type="ROR">https://ror.org/04dkp9463</idno>
          <idno type="Wikidata">Q214341</idno>
          <orgName>Universiteit van Amsterdam = University of Amsterdam</orgName>
          <orgName type="acronym">UvA</orgName>
          <date type="start">1632-01-01</date>
          <desc>
            <address>
              <addrLine>Spui 21 1012 WX Amsterdam</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.uva.nl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-5033" status="OLD">
          <idno type="IdRef">026402882</idno>
          <orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
          <date type="start">1969</date>
          <date type="end">2011</date>
          <desc>
            <address>
              <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
              <country key="FR"/>
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            <ref type="url">http://www.univmed.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
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        </org>
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
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        </org>
        <org type="institution" xml:id="struct-300302" status="VALID">
          <idno type="IdRef">027787109</idno>
          <idno type="ISNI">0000000120977052</idno>
          <idno type="ROR">https://ror.org/052bz7812</idno>
          <idno type="Wikidata">Q1546437</idno>
          <orgName>Université Paris Dauphine-PSL</orgName>
          <desc>
            <address>
              <addrLine>Place du Maréchal de Lattre de Tassigny75775 PARIS Cedex 16</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://dauphine.psl.eu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
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        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
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            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-132871" status="VALID">
          <idno type="IdRef">031660150</idno>
          <idno type="ISNI">0000000123369749</idno>
          <idno type="ROR">https://ror.org/02kkvpp62</idno>
          <idno type="Wikidata">Q157808</idno>
          <orgName>Technische Universität Munchen = Technical University Munich = Université Technique de Munich</orgName>
          <orgName type="acronym">TUM</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>Arcisstrasse 21, D- 80333 München</addrLine>
              <country key="DE"/>
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            <ref type="url">https://www.tum.de</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-460393" status="VALID">
          <idno type="ROR">https://ror.org/05591te55</idno>
          <orgName>Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München</orgName>
          <orgName type="acronym">LMU</orgName>
          <date type="start">1472-01-01</date>
          <desc>
            <address>
              <addrLine>Professor-Huber-Platz 2, 80539 München, Allemagne</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.lmu.de/en/about-lmu/index.html</ref>
          </desc>
        </org>
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</TEI>