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Article Dans Une Revue iScience Année : 2024

Mapping brain state-dependent sensory responses across the mouse cortex

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Sensory information must be integrated across a distributed brain network for stimulus processing and perception. Recent studies have revealed specific spatiotemporal patterns of cortical activation for the early and late components of sensory-evoked responses, which are associated with stimulus features and perception, respectively. Here, we investigated how the brain state influences the sensory-evoked activation across the mouse cortex. We utilized isoflurane to modulate the brain state and conducted wide-field calcium imaging of Thy1-GCaMP6f mice to monitor distributed activation evoked by multi-whisker stimulation. Our findings reveal that the level of anesthesia strongly shapes the spatiotemporal features and the functional connectivity of the sensory-activated network. As anesthesia levels decrease, we observe increasingly complex responses, accompanied by the emergence of the late component within the sensory-evoked response. The persistence of the late component under anesthesia raises new questions regarding the potential existence of perception during unconscious states.
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hal-04583644 , version 1 (22-05-2024)

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Elena Montagni, Francesco Resta, Núria Tort-Colet, Alessandro Scaglione, Giacomo Mazzamuto, et al.. Mapping brain state-dependent sensory responses across the mouse cortex. iScience, 2024, 27 (5), pp.109692. ⟨10.1016/j.isci.2024.109692⟩. ⟨hal-04583644⟩
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