<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04580995</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T18:59:58+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">LEARNING CURVE OF FUSION MRI-TARGETED PROSTATE BIOPSY AND 3D-TRUS SEGMENTATION</title>
            <author role="aut">
              <persName>
                <forename type="first">Louis</forename>
                <surname>Lenfant</surname>
              </persName>
              <idno type="idhal" notation="numeric">1280317</idno>
              <idno type="halauthorid" notation="string">2076273-1280317</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9852-4002</idno>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-1043049"/>
              <affiliation ref="#struct-541937"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clément</forename>
                <surname>Beitone</surname>
              </persName>
              <idno type="halauthorid">825609-0</idno>
              <affiliation ref="#struct-1043054"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jocelyne</forename>
                <surname>Troccaz</surname>
              </persName>
              <email type="md5">59213c8bff5e4089ab88c0f88732aef3</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">jocelyne-troccaz</idno>
              <idno type="idhal" notation="numeric">763</idno>
              <idno type="halauthorid" notation="string">25175-763</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5921-9419</idno>
              <idno type="IDREF">https://www.idref.fr/031497977</idno>
              <affiliation ref="#struct-1043054"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Morgan</forename>
                <surname>Rouprêt</surname>
              </persName>
              <idno type="halauthorid">355703-0</idno>
              <affiliation ref="#struct-353778"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Seisen</surname>
              </persName>
              <idno type="halauthorid">745432-0</idno>
              <affiliation ref="#struct-353778"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sandrine</forename>
                <surname>Voros</surname>
              </persName>
              <idno type="halauthorid">5713-0</idno>
              <affiliation ref="#struct-1043054"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Mozer</surname>
              </persName>
              <idno type="halauthorid">151011-0</idno>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-541937"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jocelyne</forename>
                <surname>Troccaz</surname>
              </persName>
              <email type="md5">59213c8bff5e4089ab88c0f88732aef3</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
            <funder ref="#projanr-50313"/>
            <funder>Projet PSPC Diana</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-05-21 09:48:24</date>
              <date type="whenWritten">2023</date>
              <date type="whenModified">2026-05-12 03:20:27</date>
              <date type="whenReleased">2024-05-22 10:13:49</date>
              <date type="whenProduced">2024-01-31</date>
              <date type="whenEndEmbargoed">2024-05-21</date>
              <ref type="file" target="https://hal.science/hal-04580995v1/document">
                <date notBefore="2024-05-21"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04580995v1/file/version-finale-auteurs.pdf" id="file-4580995-3973308">
                <date notBefore="2024-05-21"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="111277">
                <persName>
                  <forename>Jocelyne</forename>
                  <surname>Troccaz</surname>
                </persName>
                <email type="md5">59213c8bff5e4089ab88c0f88732aef3</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04580995</idno>
            <idno type="halUri">https://hal.science/hal-04580995</idno>
            <idno type="halBibtex">lenfant:hal-04580995</idno>
            <idno type="halRefHtml">&lt;i&gt;BJU International&lt;/i&gt;, 2024, 133 (6), pp.709-716. &lt;a target="_blank" href="https://dx.doi.org/10.1111/bju.16287"&gt;&amp;#x27E8;10.1111/bju.16287&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">BJU International, 2024, 133 (6), pp.709-716. &amp;#x27E8;10.1111/bju.16287&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4580995-3973308"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="ISIR" corresp="SORBONNE-UNIVERSITE">Institut des Systèmes Intelligents et de Robotique</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-GMCAO" corresp="TIMC-IMAG">GMCAO : Geste Médico-Chirurgicaux Assistés par Ordinateur</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES">Académie des sciences</idno>
            <idno type="stamp" n="SUPRA_INGENIERIE">Ingénierie</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES" corresp="ACADEMIE-SCIENCES">Publications des membres, correspondants et associés étrangers de l'Académie des sciences</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES-1" corresp="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES">Publications des membres de l'Académie des sciences (lot 1)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">LEARNING CURVE OF FUSION MRI-TARGETED PROSTATE BIOPSY AND 3D-TRUS SEGMENTATION</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Louis</forename>
                    <surname>Lenfant</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1280317</idno>
                  <idno type="halauthorid" notation="string">2076273-1280317</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9852-4002</idno>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-1043049"/>
                  <affiliation ref="#struct-541937"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clément</forename>
                    <surname>Beitone</surname>
                  </persName>
                  <idno type="halauthorid">825609-0</idno>
                  <affiliation ref="#struct-1043054"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jocelyne</forename>
                    <surname>Troccaz</surname>
                  </persName>
                  <email type="md5">59213c8bff5e4089ab88c0f88732aef3</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">jocelyne-troccaz</idno>
                  <idno type="idhal" notation="numeric">763</idno>
                  <idno type="halauthorid" notation="string">25175-763</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5921-9419</idno>
                  <idno type="IDREF">https://www.idref.fr/031497977</idno>
                  <affiliation ref="#struct-1043054"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Morgan</forename>
                    <surname>Rouprêt</surname>
                  </persName>
                  <idno type="halauthorid">355703-0</idno>
                  <affiliation ref="#struct-353778"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Seisen</surname>
                  </persName>
                  <idno type="halauthorid">745432-0</idno>
                  <affiliation ref="#struct-353778"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sandrine</forename>
                    <surname>Voros</surname>
                  </persName>
                  <idno type="halauthorid">5713-0</idno>
                  <affiliation ref="#struct-1043054"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Mozer</surname>
                  </persName>
                  <idno type="halauthorid">151011-0</idno>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-541937"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11247</idno>
                <idno type="issn">1464-4096</idno>
                <idno type="eissn">1464-410X</idno>
                <title level="j">BJU International</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">133</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">709-716</biblScope>
                  <date type="datePub">2024-01-31</date>
                  <date type="dateEpub">2024</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1111/bju.16287</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">(Mesh): Prostatic Neoplasms* / diagnostic imaging</term>
                <term xml:lang="en">Image-Guided</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="info">Computer Science [cs]</classCode>
              <classCode scheme="halDomain" n="sdv.ib.ima">Life Sciences [q-bio]/Bioengineering/Imaging</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.un">Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Objective To report the learning curve of multiple operators for fusion magnetic resonance imaging (MRI) targeted biopsy and to determine the number of cases needed to achieve proficiency. Materials and Methods All adult males who underwent fusion MRI targeted biopsy between February 2012 and July 2021 for clinically suspected prostate cancer (PCa) in a single centre were included. Fusion transrectal MRI targeted biopsy was performed under local anaesthesia using the Koelis platform. Learning curves for segmentation of transrectal ultrasonography (TRUS) images and the overall MRI targeted biopsy procedure were estimated with locally weighted scatterplot smoothing by computing each operator's timestamps for consecutive procedures. Non‐risk‐adjusted cumulative sum (CUSUM) methods were used to create learning curves for clinically significant (i.e., International Society of Urological Pathology grade ≥ 2) PCa detection. Results Overall, 1721 patients underwent MRI targeted biopsy in our centre during the study period. The median (interquartile range) times for TRUS segmentation and for the MRI targeted biopsy procedure were 4.5 (3.5, 6.0) min and 13.2 (10.6, 16.9) min, respectively. Among the 14 operators with experience of more than 50 cases, a plateau was reached after 40 cases for TRUS segmentation time and 50 cases for overall MRI targeted biopsy procedure time. CUSUM analysis showed that the learning curve for clinically significant PCa detection required 25 to 45 procedures to achieve clinical proficiency. Pain scores ranged between 0 and 1 for 84% of patients, and a plateau phase was reached after 20 to 100 cases. Conclusions A minimum of 50 cases of MRI targeted biopsy are necessary to achieve clinical and technical proficiency and to reach reproducibility in terms of timing, clinically significant PCa detection, and pain.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-353778" status="VALID">
          <idno type="ROR">https://ror.org/02mh9a093</idno>
          <orgName>CHU Pitié-Salpêtrière [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-541937" status="VALID">
          <idno type="IdRef">241179122</idno>
          <idno type="RNSR">200918463J</idno>
          <idno type="ROR">05neq8668</idno>
          <orgName>Institut des Systèmes Intelligents et de Robotique</orgName>
          <orgName type="acronym">ISIR</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Sorbonne-Université, Boite courrier 173 4 Place JUSSIEU 75252 Paris cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.isir.upmc.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR7222" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1043054" status="VALID">
          <orgName>Gestes Medico-chirurgicaux Assistés par Ordinateur</orgName>
          <orgName type="acronym">TIMC-GMCAO</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Pavillon Taillefer, Rond-point de la Croix de Vie, 38700 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/gmcao</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50313" status="VALID">
          <idno type="anr">ANR-11-LABX-0004</idno>
          <orgName>CAMI</orgName>
          <desc>Gestes Médico-Chirurgicaux Assistés par Ordinateur</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>