<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04572994</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T13:55:55+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A mouse model of sensory neuropathy induced by a long course of monomethyl-auristatin E treatment</title>
            <author role="aut">
              <persName>
                <forename type="first">Simon</forename>
                <surname>Frachet</surname>
              </persName>
              <idno type="halauthorid">1436369-0</idno>
              <affiliation ref="#struct-1088938"/>
              <affiliation ref="#struct-58106"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurore</forename>
                <surname>Danigo</surname>
              </persName>
              <email type="md5">d0e6b56764919407dfc51ce3e8edf561</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">1381695</idno>
              <idno type="halauthorid" notation="string">2232371-1381695</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6266-7690</idno>
              <idno type="IDREF">https://www.idref.fr/184029643</idno>
              <idno type="VIAF">https://viaf.org/viaf/315246797</idno>
              <affiliation ref="#struct-1088938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mathilde</forename>
                <surname>Duchesne</surname>
              </persName>
              <email type="md5">64254a31979112e7df9f6554d8fd4166</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">1140357</idno>
              <idno type="halauthorid" notation="string">588381-1140357</idno>
              <idno type="IDREF">https://www.idref.fr/270526366</idno>
              <idno type="VIAF">https://viaf.org/viaf/219169018089566982941</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5621-7335</idno>
              <affiliation ref="#struct-1088938"/>
              <affiliation ref="#struct-58106"/>
              <affiliation ref="#struct-160771"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurence</forename>
                <surname>Richard</surname>
              </persName>
              <idno type="halauthorid">603556-0</idno>
              <affiliation ref="#struct-1088938"/>
              <affiliation ref="#struct-58106"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Franck</forename>
                <surname>Sturtz</surname>
              </persName>
              <email type="md5">b46a3f0cbe9d6be075b4ed411a96289e</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">807675</idno>
              <idno type="halauthorid" notation="string">561745-807675</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6428-5162</idno>
              <idno type="IDREF">https://www.idref.fr/14387358X</idno>
              <idno type="VIAF">https://viaf.org/viaf/172830180</idno>
              <idno type="ISNI">http://isni.org/isni/0000000355966569</idno>
              <affiliation ref="#struct-1088938"/>
              <affiliation ref="#struct-160774"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Magy</surname>
              </persName>
              <email type="md5">e2ea125794cf7cf856f08483d452644b</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">911059</idno>
              <idno type="halauthorid" notation="string">370654-911059</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1784-2901</idno>
              <idno type="IDREF">https://www.idref.fr/073308161</idno>
              <idno type="VIAF">https://viaf.org/viaf/172824216</idno>
              <idno type="ISNI">http://isni.org/isni/0000000430832975</idno>
              <affiliation ref="#struct-1088938"/>
              <affiliation ref="#struct-58106"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Demiot</surname>
              </persName>
              <email type="md5">880e1f09bb05de667d781459cfd51668</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">1322014</idno>
              <idno type="halauthorid" notation="string">569679-1322014</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6199-4534</idno>
              <idno type="IDREF">https://www.idref.fr/168279347</idno>
              <idno type="VIAF">https://viaf.org/viaf/297747603</idno>
              <affiliation ref="#struct-1088938"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Accord Elsevier</forename>
                <surname>CCSD</surname>
              </persName>
              <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
              <email type="domain">ccsd.cnrs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-10-01 14:10:52</date>
              <date type="whenModified">2026-03-06 10:26:33</date>
              <date type="whenReleased">2025-10-01 14:10:53</date>
              <date type="whenProduced">2023-09</date>
              <date type="whenEndEmbargoed">2024-07-14</date>
              <ref type="file" target="https://hal.science/hal-04572994v1/document">
                <date notBefore="2024-07-14"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04572994v1/file/S0041008X23002636.pdf" id="file-5291860-4534695">
                <date notBefore="2024-07-14"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1081876">
                <persName>
                  <forename>Accord Elsevier</forename>
                  <surname>CCSD</surname>
                </persName>
                <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
                <email type="domain">ccsd.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04572994</idno>
            <idno type="halUri">https://hal.science/hal-04572994</idno>
            <idno type="halBibtex">frachet:hal-04572994</idno>
            <idno type="halRefHtml">&lt;i&gt;Toxicology and Applied Pharmacology&lt;/i&gt;, 2023, 474, pp.116624. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.taap.2023.116624"&gt;&amp;#x27E8;10.1016/j.taap.2023.116624&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Toxicology and Applied Pharmacology, 2023, 474, pp.116624. &amp;#x27E8;10.1016/j.taap.2023.116624&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-5291860-4534695"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNILIM">Université de Limoges</idno>
            <idno type="stamp" n="ELSEVIER">Import Elsevier</idno>
            <idno type="stamp" n="NEURIT" corresp="UNILIM"> Neuropathies et Innovations Thérapeutiques</idno>
            <idno type="stamp" n="OMEGAHEALTH" corresp="UNILIM">OmegaHealth</idno>
            <idno type="stamp" n="LABCIS" corresp="UNILIM">Laboratoire des Agroressources, Biomolécules et Chimie pour l’Innovation en Santé</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A mouse model of sensory neuropathy induced by a long course of monomethyl-auristatin E treatment</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Simon</forename>
                    <surname>Frachet</surname>
                  </persName>
                  <idno type="halauthorid">1436369-0</idno>
                  <affiliation ref="#struct-1088938"/>
                  <affiliation ref="#struct-58106"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurore</forename>
                    <surname>Danigo</surname>
                  </persName>
                  <email type="md5">d0e6b56764919407dfc51ce3e8edf561</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">1381695</idno>
                  <idno type="halauthorid" notation="string">2232371-1381695</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6266-7690</idno>
                  <idno type="IDREF">https://www.idref.fr/184029643</idno>
                  <idno type="VIAF">https://viaf.org/viaf/315246797</idno>
                  <affiliation ref="#struct-1088938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mathilde</forename>
                    <surname>Duchesne</surname>
                  </persName>
                  <email type="md5">64254a31979112e7df9f6554d8fd4166</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">1140357</idno>
                  <idno type="halauthorid" notation="string">588381-1140357</idno>
                  <idno type="IDREF">https://www.idref.fr/270526366</idno>
                  <idno type="VIAF">https://viaf.org/viaf/219169018089566982941</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5621-7335</idno>
                  <affiliation ref="#struct-1088938"/>
                  <affiliation ref="#struct-58106"/>
                  <affiliation ref="#struct-160771"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurence</forename>
                    <surname>Richard</surname>
                  </persName>
                  <idno type="halauthorid">603556-0</idno>
                  <affiliation ref="#struct-1088938"/>
                  <affiliation ref="#struct-58106"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Franck</forename>
                    <surname>Sturtz</surname>
                  </persName>
                  <email type="md5">b46a3f0cbe9d6be075b4ed411a96289e</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">807675</idno>
                  <idno type="halauthorid" notation="string">561745-807675</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6428-5162</idno>
                  <idno type="IDREF">https://www.idref.fr/14387358X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/172830180</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000355966569</idno>
                  <affiliation ref="#struct-1088938"/>
                  <affiliation ref="#struct-160774"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Magy</surname>
                  </persName>
                  <email type="md5">e2ea125794cf7cf856f08483d452644b</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">911059</idno>
                  <idno type="halauthorid" notation="string">370654-911059</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1784-2901</idno>
                  <idno type="IDREF">https://www.idref.fr/073308161</idno>
                  <idno type="VIAF">https://viaf.org/viaf/172824216</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000430832975</idno>
                  <affiliation ref="#struct-1088938"/>
                  <affiliation ref="#struct-58106"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Demiot</surname>
                  </persName>
                  <email type="md5">880e1f09bb05de667d781459cfd51668</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">1322014</idno>
                  <idno type="halauthorid" notation="string">569679-1322014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6199-4534</idno>
                  <idno type="IDREF">https://www.idref.fr/168279347</idno>
                  <idno type="VIAF">https://viaf.org/viaf/297747603</idno>
                  <affiliation ref="#struct-1088938"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">19664</idno>
                <idno type="issn">0041-008X</idno>
                <idno type="eissn">1096-0333</idno>
                <title level="j">Toxicology and Applied Pharmacology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">474</biblScope>
                  <biblScope unit="pp">116624</biblScope>
                  <date type="datePub">2023-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.taap.2023.116624</idno>
              <idno type="pii">S0041-008X(23)00263-6</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Antibody-drug conjugate</term>
                <term xml:lang="en">Chemotherapy</term>
                <term xml:lang="en">Monomethyl auristains E</term>
                <term xml:lang="en">Mouse model</term>
                <term xml:lang="en">Neuropathic pain</term>
                <term xml:lang="en">Peripheral neuropathy</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Antibody-drug conjugates (ADCs) are anticancer drugs consisting of a monoclonal antibody, targeting selective tumor antigens, to which has been frequently associated a highly potent cytotoxic agent, the monomethyl auristatin E (MMAE) using a chemical linker. MMAE is a tubulin polymerization inhibitor derived from dolastin-10. These MMAE-ADCs are responsible for peripheral nerve toxicities. Our objective was to develop and characterize a mouse model of MMAE-induced peripheral neuropathy induced by free MMAE injections. MMAE was injected in Swiss mice at 50 μg/kg i.p. every other day for 7 weeks. Assessments of motor and sensory nerve functions were performed once a week on MMAE and Vehicle-treated mice. Sciatic nerve and paw skin were removed at the end of experiment for subsequent immunofluorescence and morphological analysis. MMAE did not affect motor coordination, muscular strength and heat nociception, but significantly induced tactile allodynia in MMAE-treated mice compared with Vehicle-treated mice from day 35 to day 49. MMAE significantly reduced myelinated and unmyelinated axon densities in sciatic nerves and led to a loss of intraepidermal nerve fiber in paw skin. In summary, long course of low dose of MMAE induced a peripheral sensory neuropathy associated with nerve degeneration, without general state alteration. This model may represent a ready accessible tool to screen neuroprotective strategies in the context of peripheral neuropathies induced by MMAE-ADCs.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1088938" status="VALID">
          <idno type="IdRef">188403140</idno>
          <idno type="RNSR">201220218D</idno>
          <idno type="ROR">https://ror.org/040rsxp47</idno>
          <idno type="Wikidata">Q135095674</idno>
          <orgName>Neuropathies et Innovations Thérapeutiques</orgName>
          <orgName type="acronym">NEURIT</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine, 2 Rue du Docteur Marcland 87025 LIMOGES Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/ur20218-neurit/</ref>
          </desc>
          <listRelation>
            <relation name="UR20218" active="#struct-1088917" type="direct"/>
            <relation active="#struct-5928" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-58106" status="VALID">
          <orgName>Service de Neurologie [CHU Limoges]</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren 2 avenue Martin-Luther-King 87042 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-160771" status="VALID">
          <orgName>Service d'Anatomie Pathologique [CHU Limoges]</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Dupuytren 2, avenue Martin Luther King 87042 Limoges</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-160774" status="VALID">
          <orgName>Service de Biochimie et Génétique Moléculaire [CHU Limoges]</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren 2, avenue Martin Luther King 87042 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1088917" status="VALID">
          <idno type="IdRef">224565699</idno>
          <orgName>OmégaHealth</orgName>
          <orgName type="acronym">ΩHealth</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/recherche/laboratoires/omegahealth/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-5928" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-5928" status="VALID">
          <idno type="IdRef">026403315</idno>
          <idno type="ISNI">0000000121654861</idno>
          <idno type="ROR">https://ror.org/02cp04407</idno>
          <orgName>Université de Limoges</orgName>
          <orgName type="acronym">UNILIM</orgName>
          <date type="start">1968-10-01</date>
          <desc>
            <address>
              <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300906" status="VALID">
          <idno type="ROR">https://ror.org/01tc2d264</idno>
          <orgName>CHU Limoges</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>