Magnetic Membranes for Cell Growth Under Curved and Reversible Deformations - Archive ouverte HAL Access content directly
Journal Articles Small Science Year : 2024

Magnetic Membranes for Cell Growth Under Curved and Reversible Deformations

Abstract

Magnetic polymer composites are very versatile candidates to fabricate soft robots and actuators thanks to their unique properties such as flexibility and shape memory effect. Thus, the possibility to reproduce natural shapes provides new tools for bioengineering applications. The wide panel of deformations of magnetic polymer composites can be implemented to mimic the movements and curvatures of living tissue. Herein, magnetic polymer membranes are developed to explore cell growth under curved, reversible, and controlled deformations. NdFeB/polydimethylsiloxane composite membranes (86 μm and 46 μm thick) are obtained by soft lithography and magnetized in rolled position under 3 T. Once actuated by a low magnetic field (5–86 mT), the membranes are deformed in wavy shapes with a deformation height of maximum 1.4 and 1.7 mm and a curvature radius of minimum 1.8 and 0.6 mm (86 μm and 46 μm thick membranes, respectively), for a maximum magnetic field of 86 mT. Then, Caco‐2 cell viability is studied on deformed substrates under a static (106 mT) and varying (8–78 mT) magnetic field. No increase in cell death is observed, validating a well‐characterized and promising approach for a new generation of dynamic and curved substrates for cell culture.
Fichier principal
Vignette du fichier
Small Science - 2024 - Chalut - Magnetic Membranes for Cell Growth Under Curved and Reversible Deformations.pdf (3.4 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive
Licence

Dates and versions

hal-04572954 , version 1 (13-05-2024)

Licence

Identifiers

Cite

Valentin Chalut, Damien Le Roy, Thibault Mercier, Marie‐Charlotte Audry, Victor Vieille, et al.. Magnetic Membranes for Cell Growth Under Curved and Reversible Deformations. Small Science, In press, pp.2400141. ⟨10.1002/smsc.202400141⟩. ⟨hal-04572954⟩
0 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More