HMPA-Free Synthesis of TMS-Substituted Alkynes
Résumé
TMS-substituted alkynes are versatile building blocks in organic synthesis. Traditional synthesis involves alkyne deprotonation and the reaction with TMSCl. Recently, TMS-acetylene has become an increasingly inexpensive bulk chemical, offering an attractive alternative to accessing TMS-substituted alkynes, especially when the alkyne is expensive or not commercially available. However, this route has been established with carcinogenic HMPA as a cosolvent. In this work, we disclose optimized conditions utilizing DMPU as a substitute for HMPA.