<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04570965</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T07:56:35+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Cloning, expression and pharmacological characterization of a vasopressin-related receptor in an annelid, the leech Theromyzon tessulatum</title>
            <author role="aut">
              <persName>
                <forename type="first">A</forename>
                <surname>Levoye</surname>
              </persName>
              <idno type="halauthorid">3146381-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B</forename>
                <surname>Mouillac</surname>
              </persName>
              <idno type="halauthorid">3146382-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Rivière</surname>
              </persName>
              <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="string">guillaume-riviere</idno>
              <idno type="idhal" notation="numeric">179950</idno>
              <idno type="halauthorid" notation="string">5040-179950</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8372-8715</idno>
              <idno type="IDREF">https://www.idref.fr/094812063</idno>
              <affiliation ref="#struct-542153"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D</forename>
                <surname>Vieau</surname>
              </persName>
              <idno type="halauthorid">3146383-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M</forename>
                <surname>Salzet</surname>
              </persName>
              <idno type="halauthorid">3146384-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C</forename>
                <surname>Breton</surname>
              </persName>
              <idno type="halauthorid">3146385-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Guillaume</forename>
                <surname>Riviere</surname>
              </persName>
              <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
              <email type="domain">unicaen.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-05-07 14:19:49</date>
              <date type="whenModified">2025-03-28 17:38:09</date>
              <date type="whenReleased">2024-05-07 14:19:49</date>
              <date type="whenProduced">2005-01</date>
              <ref type="externalLink" target="https://joe.bioscientifica.com/downloadpdf/journals/joe/184/1/1840277.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="748099">
                <persName>
                  <forename>Guillaume</forename>
                  <surname>Riviere</surname>
                </persName>
                <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
                <email type="domain">unicaen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04570965</idno>
            <idno type="halUri">https://hal.science/hal-04570965</idno>
            <idno type="halBibtex">levoye:hal-04570965</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Endocrinology&lt;/i&gt;, 2005, 184 (1), pp.277-289. &lt;a target="_blank" href="https://dx.doi.org/10.1677/joe.1.05833"&gt;&amp;#x27E8;10.1677/joe.1.05833&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Endocrinology, 2005, 184 (1), pp.277-289. &amp;#x27E8;10.1677/joe.1.05833&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="MNHN">Muséum National d'Histoire Naturelle</idno>
            <idno type="stamp" n="UNIV-AG">Université des Antilles</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="BOREA" corresp="SORBONNE-UNIVERSITE">Biologie des Organismes Aquatiques et Ecosystèmes</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-INF-2018" corresp="SORBONNE-UNIVERSITE">SORBONNE université &lt;2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="BOREA-CAEN">Publications des chercheurs caennais de l'UMR BOREA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Cloning, expression and pharmacological characterization of a vasopressin-related receptor in an annelid, the leech Theromyzon tessulatum</title>
                <author role="aut">
                  <persName>
                    <forename type="first">A</forename>
                    <surname>Levoye</surname>
                  </persName>
                  <idno type="halauthorid">3146381-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B</forename>
                    <surname>Mouillac</surname>
                  </persName>
                  <idno type="halauthorid">3146382-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Rivière</surname>
                  </persName>
                  <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="string">guillaume-riviere</idno>
                  <idno type="idhal" notation="numeric">179950</idno>
                  <idno type="halauthorid" notation="string">5040-179950</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8372-8715</idno>
                  <idno type="IDREF">https://www.idref.fr/094812063</idno>
                  <affiliation ref="#struct-542153"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D</forename>
                    <surname>Vieau</surname>
                  </persName>
                  <idno type="halauthorid">3146383-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M</forename>
                    <surname>Salzet</surname>
                  </persName>
                  <idno type="halauthorid">3146384-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C</forename>
                    <surname>Breton</surname>
                  </persName>
                  <idno type="halauthorid">3146385-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15408</idno>
                <idno type="issn">0022-0795</idno>
                <idno type="eissn">1479-6805</idno>
                <title level="j">Journal of Endocrinology</title>
                <imprint>
                  <publisher>BioScientifica</publisher>
                  <biblScope unit="volume">184</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">277-289</biblScope>
                  <date type="datePub">2005-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1677/joe.1.05833</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>In annelids, it has been established that arginine-vasopressin (AVP)/oxytocin (OT) superfamily peptides are involved in the maintenance of water and electrolyte homeostasis as well as reproduction. At present, there is little information on their receptors. In this study, we report the characterization of a 1.7 kb cDNA for an AVP-related receptor from the leech Theromyzon tessulatum . The open reading frame encodes a 435-aminoacid transmembrane protein that displays seven segments of hydrophobic amino acids, typical of G-protein-coupled receptors. The overall predicted protein exhibits about 30% amino-acid identities to other invertebrate, as well as vertebrate, AVP/OT receptor family members, and displays conserved characteristic features belonging to the AVP/OT receptor superfamily. RT-PCR expression experiments showed that mRNA is expressed in the genital tract, the ovary and the brain. The receptor expression is stage specific, showing a weak expression after the two first blood meals, increasing dramatically after the last blood meal during the period of sexual maturation and disappearing after egg laying. Thus, the leech AVP-related receptor may mediate reproductive functions. When expressed in COS-7 cells, the receptor binds ligands with the following rank order of potency: AVP= Arg-vasotocin &gt;Arg-conopressin &gt;mesotocin = OT = Lys-conopressin=isotocin&gt;annetocin. This shows an AVP-like pharmacological profile. The transfected receptor mediates AVP-induced accumulation of inositol phosphates, indicating that the leech AVP-related receptor is functional. This study describes the characterization of a novel AVP/OT superfamily receptor in annelids, which are considered the most distant group of coelomate metazoans possessing a functional AVP/OT-related endocrine system.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-542153" status="OLD">
          <idno type="IdRef">184555752</idno>
          <idno type="ISNI">0000 0004 0370 7482</idno>
          <idno type="RNSR">200919362L</idno>
          <idno type="ROR">https://ror.org/01tp1c480</idno>
          <idno type="Wikidata">Q30262180</idno>
          <orgName>Biologie des Organismes et Ecosystèmes Aquatiques</orgName>
          <orgName type="acronym">BOREA</orgName>
          <date type="start">2014-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Muséum national d'Histoire naturelle - 7, rue Cuvier - CP 32 - 75231 Paris Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://borea.mnhn.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-7512" type="direct"/>
            <relation active="#struct-67872" type="direct"/>
            <relation name="UM95" active="#struct-413221" type="direct"/>
            <relation name="UMR8067 / FRE2030 / UMR7208" active="#struct-441569" type="direct"/>
            <relation active="#struct-524399" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-7512" status="VALID">
          <idno type="IdRef">026394944</idno>
          <idno type="ROR">https://ror.org/03wkt5x30</idno>
          <orgName>Muséum national d'Histoire naturelle</orgName>
          <orgName type="acronym">MNHN</orgName>
          <desc>
            <address>
              <addrLine>57, rue Cuvier - 75231 Paris Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.mnhn.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-524399" status="VALID">
          <idno type="IdRef">187841578</idno>
          <idno type="ROR">https://ror.org/02ryfmr77</idno>
          <orgName>Université des Antilles</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-antilles.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>